Browsing by Subject "Biosynthetic gene cluster"

Browsing by Subject "Biosynthetic gene cluster"

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  • Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi 
    Szwalbe, Agniezka J.; Williams, Katherine; Song, Zhongshu; De Mattos-Shipley, Kate M.J.; Vincent, Jason L.; Bailey, Andrew M.; Willis, Christine L.; Cox, Russell J.; Simpson, Thomas J. (Cambridge : Royal Society of Chemistry, 2019)
    Two new dihydroxy-xanthone metabolites, agnestins A and B, were isolated from Paecilomyces variotii along with a number of related benzophenones and xanthones including monodictyphenone. The structures were elucidated by ...
  • Investigating the biosynthesis of Sch-642305 in the fungus : Phomopsis sp. CMU-LMA 
    Trenti, Francesco; Lebe, Karen E.; Adelin, Emilie; Ouazzani, Jamal; Schotte, Carsten; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2020)
    Sch-642305 is an unusual bicyclic 10-membered macrolide produced by the filamentous fungus Phomopsis sp. CMU-LMA for which no biosynthetic evidence exists. Here, we generate a draft genome sequence of the producing organism ...
  • The Peptide Antibiotic Corramycin Adopts a β-Hairpin-like Structure and Is Inactivated by the Kinase ComG 
    Adam, Sebastian; Fries, Franziska; Tesmar, Alexander von; Rasheed, Sari; Deckarm, Selina; Sousa, Carla F.; Reberšek, Roman; Risch, Timo; Mancini, Stefano; Herrmann, Jennifer; Koehnke, Jesko; Kalinina, Olga V.; Müller, Rolf (Washington, DC : ACS Publications, 2024)
    The rapid development of antibiotic resistance, especially among difficult-to-treat Gram-negative bacteria, is recognized as a serious and urgent threat to public health. The detection and characterization of novel resistance ...