Browsing by Subject "Biosynthesis"

Sort by: Order: Results:

  • Azaphilone Pigments from Hypoxylon rubiginosum and H. texense: Absolute Configuration, Bioactivity, and Biosynthesis 
    Becker, Kevin; Kuhnert, Eric; Cox, Russell J.; Surup, Frank (Weinheim : Wiley-VCH Verl., 2021)
    We report new stromatal azaphilone pigments rubiginosins Z-X from the ascomycete Hypoxylon rubiginosum, as well as rubiginosins Z and W from H. texense, which were isolated along with known monomeric and dimeric congeners. ...
  • Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides 
    Hemmerling, Franziska; Hahn, Frank (Frankfurt am Main : Beilstein-Institut zur Förderung der Chemischen Wissenschaften, 2016)
    This review highlights the biosynthesis of heterocycles in polyketide natural products with a focus on oxygen and nitrogen-containing heterocycles with ring sizes between 3 and 6 atoms. Heterocycles are abundant structural ...
  • Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi 
    Szwalbe, Agniezka J.; Williams, Katherine; Song, Zhongshu; De Mattos-Shipley, Kate M.J.; Vincent, Jason L.; Bailey, Andrew M.; Willis, Christine L.; Cox, Russell J.; Simpson, Thomas J. (Cambridge : Royal Society of Chemistry, 2019)
    Two new dihydroxy-xanthone metabolites, agnestins A and B, were isolated from Paecilomyces variotii along with a number of related benzophenones and xanthones including monodictyphenone. The structures were elucidated by ...
  • The cycloaspeptides: Uncovering a new model for methylated nonribosomal peptide biosynthesis 
    De Mattos-Shipley, Kate M.J.; Greco, Claudio; Heard, David M.; Hough, Gemma; Mulholland, Nicholas P.; Vincent, Jason L.; Micklefield, Jason; Simpson, Thomas J.; Willis, Christine L.; Cox, Russell J.; Bailey, Andrew M. (Cambridge : Royal Society of Chemistry, 2018)
    The cycloaspeptides are bioactive pentapeptides produced by various filamentous fungi, which have garnered interest from the agricultural industry due to the reported insecticidal activity of the minor metabolite, ...
  • Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis 
    Williams, Katherine; Szwalbe, Agnieszka J.; Mulholland, Nicholas P.; Vincent, Jason L.; Bailey, Andrew M.; Willis, Christine L.; Simpson, Thomas J.; Cox, Russell J. (Weinheim : Wiley-VCH Verlag, 2016)
    Fungal maleidrides are an important family of bioactive secondary metabolites that consist of 7, 8, or 9-membered carbocycles with one or two fused maleic anhydride moieties. The biosynthesis of byssochlamic acid (a ...
  • In vivo characterization of key iridoid biosynthesis pathway genes in catnip (Nepeta cataria) 
    Palmer, Lira; Chuang, Ling; Siegmund, Marlen; Kunert, Maritta; Yamamoto, Kotaro; Sonawane, Prashant; O’Connor, Sarah E. (Berlin ; Heidelberg : Springer, 2022)
    Main conclusion: Using virus-induced gene silencing, we demonstrated that the enzymes GES, ISY, and MLPL are responsible for nepetalactone biosynthesis in Nepeta cataria. Abstract: Nepetalactone is the main iridoid that ...
  • Investigating the biosynthesis of Sch-642305 in the fungus : Phomopsis sp. CMU-LMA 
    Trenti, Francesco; Lebe, Karen E.; Adelin, Emilie; Ouazzani, Jamal; Schotte, Carsten; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2020)
    Sch-642305 is an unusual bicyclic 10-membered macrolide produced by the filamentous fungus Phomopsis sp. CMU-LMA for which no biosynthetic evidence exists. Here, we generate a draft genome sequence of the producing organism ...
  • The native structure and composition of the cruciferin complex in brassica napus 
    Nietzel, Thomas; Dudkina, Natalya V.; Haase, Christin; Denolf, Peter; Semchonok, Dmitry A.; Boekema, Egbert J.; Braun, Hans-Peter; Sunderhaus, Stephanie (Bethesda, Md. : ASBMB Publications, 2013)
    Globulins are an important group of seed storage proteins in dicotyledonous plants. They are synthesized during seed development, assembled into very compact protein complexes, and finally stored in protein storage vacuoles ...
  • Natural products isolation from Trichoderma reesei 
    Shenouda, Mary Labib Kamel Labib (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2022)
    The focus of the present work is to develop Trichoderma reesei as a heterologous host for the production of natural products and to explore the biosynthetic potential of this fungus by expressing one of its cryptic PKS-NRPS ...
  • Orange, red, yellow: Biosynthesis of azaphilone pigments in Monascus fungi 
    Chen, Wanping; Chen, Runfa; Liu, Qingpei; He, Yi; He, Kun; Ding, Xiaoli; Kang, Lijing; Guo, Xiaoxiao; Xie, Nana; Zhou, Youxiang; Lu, Yuanyuan; Cox, Russell J.; Molnár, Istvan; Li, Mu; Shao, Yanchun; Chen, Fusheng (Cambridge : Royal Society of Chemistry, 2017)
    Monascus azaphilone pigments (MonAzPs) are very widely used as food colorants, but their biosynthetic pathway has remained poorly characterized for more than half a century. In this study, the individual steps of MonAzPs ...
  • Oxidative steps during the biosynthesis of squalestatin S1 
    Lebe, Karen E.; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2018)
    The squalestatins are a class of highly complex fungal metabolites which are potent inhibitors of squalene synthase with potential use in the control of cholesterol biosynthesis. Little is known of the chemical steps ...
  • Secondary metabolite biosynthetic diversity in the fungal family Hypoxylaceae and Xylaria hypoxylon 
    Kuhnert, E.; Navarro-Muñoz, J.C.; Becker, K.; Stadler, M.; Collemare, J.; Cox, R.J. (Amsterdam [u.a.] : Elsevier, 2021)
    To date little is known about the genetic background that drives the production and diversification of secondary metabolites in the Hypoxylaceae. With the recent availability of high-quality genome sequences for 13 ...
  • Single organelle function and organization as estimated from Arabidopsis mitochondrial proteomics 
    Fuchs, Philippe; Rugen, Nils; Carrie, Chris; Elsässer, Marlene; Finkemeier, Iris; Giese, Jonas; Hildebrandt, Tatjana M.; Kühn, Kristina; Maurino, Veronica G.; Ruberti, Cristina; Schallenberg-Rüdinger, Mareike; Steinbeck, Janina; Braun, Hans-Peter; Eubel, Holger; Meyer, Etienne H.; Müller-Schüssele, Stefanie J.; Schwarzländer, Markus (Oxford [u.a.] : Wiley-Blackwell, 2020)
    Mitochondria host vital cellular functions, including oxidative phosphorylation and co-factor biosynthesis, which are reflected in their proteome. At the cellular level plant mitochondria are organized into hundreds of ...
  • The sporothriolides. A new biosynthetic family of fungal secondary metabolites 
    Tian, Dong-Song; Kuhnert, Eric; Ouazzani, Jamal; Wibberg, Daniel; Kalinowski, Jörn; Cox, Russell J. (Cambridge : RSC, 2020)
    The biosynthetic gene cluster of the antifungal metabolite sporothriolide 1 was identified from three producing ascomycetes: Hypomontagnella monticulosa MUCL 546, H. spongiphila CLL 205 and H. submonticulosa DAOMC 242471. ...
  • Sulfonium Acids Loaded onto an Unusual Thiotemplate Assembly Line Construct the Cyclopropanol Warhead of a Burkholderia Virulence Factor 
    Trottmann, Felix; Ishida, Keishi; Franke, Jakob; Stanišić, Aleksa; Ishida-Ito, Mie; Kries, Hajo; Pohnert, Georg; Hertweck, Christian (Weinheim : Wiley-VCH, 2020)
    Pathogenic bacteria of the Burkholderia pseudomallei group cause severe infectious diseases such as glanders and melioidosis. Malleicyprols were identified as important bacterial virulence factors, yet the biosynthetic ...
  • Synthesis of model cytochalasan precursors and in vitro studies of their activities 
    Zhang, Haili (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2020)
    Cytochalasans are one type of PKS-NRPS secondary metabolites. The tailoring steps involved in cytochalasan biosynthesis are almost clear, but the formation of the isoindolone core is still mysterious. The ACE1 metabolite ...
  • Uncovering biosynthetic relationships between antifungal nonadrides and octadrides 
    De Mattos-Shipley, Kate M. J.; Spencer, Catherine E.; Greco, Claudio; Heard, David M.; O'Flynn, Daniel E.; Dao, Trong T.; Song, Zhongshu; Mulholland, Nicholas P.; Vincent, Jason L.; Simpson, Thomas J.; Cox, Russell J.; Bailey, Andrew M.; Willis, Christine L. (Cambridge : RSC, 2020)
    Maleidrides are a class of bioactive secondary metabolites unique to filamentous fungi, which contain one or more maleic anhydrides fused to a 7-, 8- or 9- membered carbocycle (named heptadrides, octadrides and nonadrides ...
  • Untersuchung von Schlüsselenzymen der Ambruticin-Biosynthese und deren Nutzbarkeit für die chemoenzymatische Synthese 
    Berkhan, Gesche (Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2016)
    [no abstract]
  • Xenogeneic modulation of the ClpCP protease of Bacillus subtilis by a phage-encoded adaptor-like protein 
    Mulvenna, N.; Hantke, I.; Burchell, L.; Nicod, S.; Bell, D.; Turgay, K.; Wigneshweraraj, S. (Rockville, MD : American Society for Biochemistry and Molecular Biology Inc., 2019)
    Like eukaryotic and archaeal viruses, which coopt the host's cellular pathways for their replication, bacteriophages have evolved strategies to alter the metabolism of their bacterial host. SPO1 bacteriophage infection of ...