Browsing by Subject "Biosynthesis"

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  • Hemmerling, Franziska; Hahn, Frank (Frankfurt am Main : Beilstein-Institut zur Förderung der Chemischen Wissenschaften, 2016)
    This review highlights the biosynthesis of heterocycles in polyketide natural products with a focus on oxygen and nitrogen-containing heterocycles with ring sizes between 3 and 6 atoms. Heterocycles are abundant structural ...
  • Szwalbe, Agniezka J.; Williams, Katherine; Song, Zhongshu; De Mattos-Shipley, Kate M.J.; Vincent, Jason L.; Bailey, Andrew M.; Willis, Christine L.; Cox, Russell J.; Simpson, Thomas J. (Cambridge : Royal Society of Chemistry, 2019)
    Two new dihydroxy-xanthone metabolites, agnestins A and B, were isolated from Paecilomyces variotii along with a number of related benzophenones and xanthones including monodictyphenone. The structures were elucidated by ...
  • De Mattos-Shipley, Kate M.J.; Greco, Claudio; Heard, David M.; Hough, Gemma; Mulholland, Nicholas P.; Vincent, Jason L.; Micklefield, Jason; Simpson, Thomas J.; Willis, Christine L.; Cox, Russell J.; Bailey, Andrew M. (Cambridge : Royal Society of Chemistry, 2018)
    The cycloaspeptides are bioactive pentapeptides produced by various filamentous fungi, which have garnered interest from the agricultural industry due to the reported insecticidal activity of the minor metabolite, ...
  • Williams, Katherine; Szwalbe, Agnieszka J.; Mulholland, Nicholas P.; Vincent, Jason L.; Bailey, Andrew M.; Willis, Christine L.; Simpson, Thomas J.; Cox, Russell J. (Weinheim : Wiley-VCH Verlag, 2016)
    Fungal maleidrides are an important family of bioactive secondary metabolites that consist of 7, 8, or 9-membered carbocycles with one or two fused maleic anhydride moieties. The biosynthesis of byssochlamic acid (a ...
  • Trenti, Francesco; Lebe, Karen E.; Adelin, Emilie; Ouazzani, Jamal; Schotte, Carsten; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2020)
    Sch-642305 is an unusual bicyclic 10-membered macrolide produced by the filamentous fungus Phomopsis sp. CMU-LMA for which no biosynthetic evidence exists. Here, we generate a draft genome sequence of the producing organism ...
  • Nietzel, Thomas; Dudkina, Natalya V.; Haase, Christin; Denolf, Peter; Semchonok, Dmitry A.; Boekema, Egbert J.; Braun, Hans-Peter; Sunderhaus, Stephanie (Bethesda, Md. : ASBMB Publications, 2013)
    Globulins are an important group of seed storage proteins in dicotyledonous plants. They are synthesized during seed development, assembled into very compact protein complexes, and finally stored in protein storage vacuoles ...
  • Shenouda, Mary Labib Kamel Labib (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2022)
    The focus of the present work is to develop Trichoderma reesei as a heterologous host for the production of natural products and to explore the biosynthetic potential of this fungus by expressing one of its cryptic PKS-NRPS ...
  • Chen, Wanping; Chen, Runfa; Liu, Qingpei; He, Yi; He, Kun; Ding, Xiaoli; Kang, Lijing; Guo, Xiaoxiao; Xie, Nana; Zhou, Youxiang; Lu, Yuanyuan; Cox, Russell J.; Molnár, Istvan; Li, Mu; Shao, Yanchun; Chen, Fusheng (Cambridge : Royal Society of Chemistry, 2017)
    Monascus azaphilone pigments (MonAzPs) are very widely used as food colorants, but their biosynthetic pathway has remained poorly characterized for more than half a century. In this study, the individual steps of MonAzPs ...
  • Lebe, Karen E.; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2018)
    The squalestatins are a class of highly complex fungal metabolites which are potent inhibitors of squalene synthase with potential use in the control of cholesterol biosynthesis. Little is known of the chemical steps ...
  • Kuhnert, E.; Navarro-Muñoz, J.C.; Becker, K.; Stadler, M.; Collemare, J.; Cox, R.J. (Amsterdam [u.a.] : Elsevier, 2021)
    To date little is known about the genetic background that drives the production and diversification of secondary metabolites in the Hypoxylaceae. With the recent availability of high-quality genome sequences for 13 ...
  • Fuchs, Philippe; Rugen, Nils; Carrie, Chris; Elsässer, Marlene; Finkemeier, Iris; Giese, Jonas; Hildebrandt, Tatjana M.; Kühn, Kristina; Maurino, Veronica G.; Ruberti, Cristina; Schallenberg-Rüdinger, Mareike; Steinbeck, Janina; Braun, Hans-Peter; Eubel, Holger; Meyer, Etienne H.; Müller-Schüssele, Stefanie J.; Schwarzländer, Markus (Oxford [u.a.] : Wiley-Blackwell, 2020)
    Mitochondria host vital cellular functions, including oxidative phosphorylation and co-factor biosynthesis, which are reflected in their proteome. At the cellular level plant mitochondria are organized into hundreds of ...
  • Trottmann, Felix; Ishida, Keishi; Franke, Jakob; Stanišić, Aleksa; Ishida-Ito, Mie; Kries, Hajo; Pohnert, Georg; Hertweck, Christian (Weinheim : Wiley-VCH, 2020)
    Pathogenic bacteria of the Burkholderia pseudomallei group cause severe infectious diseases such as glanders and melioidosis. Malleicyprols were identified as important bacterial virulence factors, yet the biosynthetic ...
  • Zhang, Haili (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2020)
    Cytochalasans are one type of PKS-NRPS secondary metabolites. The tailoring steps involved in cytochalasan biosynthesis are almost clear, but the formation of the isoindolone core is still mysterious. The ACE1 metabolite ...
  • De Mattos-Shipley, Kate M. J.; Spencer, Catherine E.; Greco, Claudio; Heard, David M.; O'Flynn, Daniel E.; Dao, Trong T.; Song, Zhongshu; Mulholland, Nicholas P.; Vincent, Jason L.; Simpson, Thomas J.; Cox, Russell J.; Bailey, Andrew M.; Willis, Christine L. (Cambridge : RSC, 2020)
    Maleidrides are a class of bioactive secondary metabolites unique to filamentous fungi, which contain one or more maleic anhydrides fused to a 7-, 8- or 9- membered carbocycle (named heptadrides, octadrides and nonadrides ...
  • Berkhan, Gesche (Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2016)
    [no abstract]
  • Mulvenna, N.; Hantke, I.; Burchell, L.; Nicod, S.; Bell, D.; Turgay, K.; Wigneshweraraj, S. (Rockville, MD : American Society for Biochemistry and Molecular Biology Inc., 2019)
    Like eukaryotic and archaeal viruses, which coopt the host's cellular pathways for their replication, bacteriophages have evolved strategies to alter the metabolism of their bacterial host. SPO1 bacteriophage infection of ...