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Browsing by Subject "Biosynthese"

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Biosynthesis of fungal alkyl citrates and polyketides

Yin, Sen (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2020)

Das Hauptaugenmerk der vorgestellten Arbeit lag auf dem Verständnis des Biosynthesewegs von Viridofungin, der Untersuchung der enzymatischen Eigenschaften der Schlüsselenzyme aus dem Byssochlaminsäure-Weg und der Entwicklung ...
The biosynthesis of phyllostictine A and Sch-642305 from Phyllosticta cirsii and Phomopsis CMU-LMA

Trenti, Francesco (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2018)

The presented work focuses on the biosynthesis of fungal natural products. Structural analysis of phyllostictine A revealed the literature structure to be erroneous and led to the revised bicyclic 3-methylene tetramic ...
Biosynthesis of Xenovulenes in Acremonium strictum

Schor, Raissa (Hannover : Insititutionelles Repositorium der Leibniz Universität Hannover, 2018)

Xenovulenes are a family of fungal meroterpenoids produced by the ascomycete Acremonium strictum. Xenovulene A binds the GABA receptor in vitro. The compound exhibits an unusual tetrahydrofuro-cyclopentenone attached to a ...
Expression and engineering of biosynthetic enzymes in fungi

Jin, Feng (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2021-07-14)

Fungal heterologous expression is a powerful tool for the production of natural products. In this presented work, we aim to further expand the application of fungal heterologous systems. In addition to iterative PKS, ...
In vitro-Untersuchungen von Schlüsselschritten der Borrelidin- und Ambruticin-Biosynthesen

Kandziora, Nadine (Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2015)

[no abstract]
Investigating and engineering fungal tropolone meroterpenoid biosynthesis

Li, Lei (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2022)

The main focus of the presented work concentrated on understanding the biosynthetic pathways of tropolone sesquiterpenoids (TS) and scytolide in fungi. Tropolone sesquiterpenoids, such as pycnidione 22 and eupenifeldin ...
Investigating the biosynthesis of the fungal metabolites Squalestatin S1, Strobilurin A and SCH–642305

Lebe, Karen Elisabeth (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2020)

The main focus of the presented work concentrated on understanding and engineering the biosynthesis of three polyketides produced by filamentous fungi: squalestatin S1, strobilurin A and SCH–642305. In a combined genetic ...
Lebensmittelchemie 2012

Berger, Ralf G.; Schrader, Jens; Schwab, Wilfried; Wüst, Matthias; Zorn, Holger (Berlin : De Gruyter, 2013)

Neben der Identifizierung von Aromastoffen durch die molekulare Sensorik sind die Aufklärung ihrer ‧Biosynthese sowie ihre biotechnische Produktion ins Zentrum der Aromastoffforschung gerückt. Geruch und Geschmack vermitteln ...
Natural products isolation from Trichoderma reesei

Shenouda, Mary Labib Kamel Labib (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2022)

The focus of the present work is to develop Trichoderma reesei as a heterologous host for the production of natural products and to explore the biosynthetic potential of this fungus by expressing one of its cryptic PKS-NRPS ...
Oxidative rearrangements during fungal biosynthesis

Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2014-07-25)

Oxidative rearrangements are key reactions during the biosyntheses of many secondary metabolites in fungi. This review highlights the most important examples of these reactions and aims to draw together key mechanistic ...
Rational engineering of an iterative polyketide synthase

Schmidt, Katharina (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2024)

The focus of the presented work is the engineering of polyketide-derived natural products in different stages of their biosynthesis. Within this context, one project centres on the engineering of a polyketide synthase ...
Synthesis of model cytochalasan precursors and in vitro studies of their activities

Zhang, Haili (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2020)

Cytochalasans are one type of PKS-NRPS secondary metabolites. The tailoring steps involved in cytochalasan biosynthesis are almost clear, but the formation of the isoindolone core is still mysterious. The ACE1 metabolite ...
Understanding and engineering the biosynthesis of tropolone sesquiterpenoids in fungi

Schotte, Carsten (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2021)

Tropolone sesquiterpenoids (TS) are meroterpenoid natural products that share the conserved structural feature of a polyketide-derived tropolone nucleus connected to a humulene-derived macrocycle via a bridging dihydropyran ...
Understanding and exploiting fungal PKS-NRPS biosynthesis in Pyricularia and Magnaporthe species

Hantke, Verena (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2019)

The fungus Pyricularia oryzae is a major pathogen of rice (Oryzae sativa) that causes substantial loss of yields every year. Remarkably, certain rice strains carrying the Pi33 gene are resistant to strains of P. oryzae ...
Understanding and Exploiting the Fungal Biosynthesis of Bisorbicillinoids and Terrein

Kahlert, Lukas (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2021)

The biosynthetic pathways towards the polyketides terrein and (dimeric) sorbicillinoids, such as the Diels-Alder derived bisorbicillinol, were investigated. Both pathways were reconstituted step by step in Aspergillus ...
Understanding, engineering and chemical modification of pyrichalasin H biosynthesis from Magnaporthe grisea NI980

Wang, Chongqing (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2020)

Pyrichalasin H 65 belongs to the cytochalasan family of fungal natural products, and is the major phytotoxic metabolite produced by the fungal plant pathogen Magnaporthe grisea NI980. In a combined chemical and genetic ...
Untersuchung von Schlüsselenzymen der Ambruticin-Biosynthese und deren Nutzbarkeit für die chemoenzymatische Synthese

Berkhan, Gesche (Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2016)

[no abstract]
Über den Zusammenhang der Biogenese von Anthocyan und Leukoanthocyan

Bopp, Martin; Matthiss, Blanka (Berlin, Boston : De Gruyter, 1962)

Es wurden Markierungsversuche mit Phenylalanin (Carboxyl-14C) zur Kennzeichnung des Biosynthesewegs der Leukoanthocyane bei Impatiens balsamina vorgenommen. Unter geeigneten Umständen wird Phenylalanin genau so in die ...
Der Vitamin B1-Gehalt von Tradescantia-Blättern in Abhängigkeit von der Wellenlänge des Lichtes

Ruge, U. (Berlin : De Gruyter, 1959)

Die Biosynthese von Biowuchsstoffen ist von der Wellenlänge des Lichtes abhängig. Sie wird durch den Spektralbereich > 630 mμ schwach gefördert, stärker durch den > 435 mμ und < 505 mμ; gehemmt wird dieser Prozeß dagegen ...
Withanolides: Elucidating steroidal lactone biosynthesis in Nightshades

Stein, Annika (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2022)

Withania somnifera (Solanaceae) is well known in ayurvedic medicine as a strengthening tonic for various medical purposes. Its effects are mainly due to withanolides, a class of steroidal lactones with diverse oxidation ...

Now showing items 1-20 of 20

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