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Browsing by Subject "Bioreactors"

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Continuous optical in-line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality

Lederle, Mario; Tric, Mircea; Roth, Tatjana; Schütte, Lina; Rattenholl, Anke; Lütkemeyer, Dirk; Wölfl, Stefan; Werner, Tobias; Wiedemann, Philipp (Weinheim : Wiley-VCH, 2021)

Great efforts are directed towards improving productivity, consistency and quality of biopharmaceutical processes and products. One particular area is the development of new sensors for continuous monitoring of critical ...
Dynamic cultivation of human mesenchymal stem/stromal cells for the production of extracellular vesicles in a 3D bioreactor system

Almeria, Ciarra; Weiss, René; Keck, Maike; Weber, Viktoria; Kasper, Cornelia; Egger, Dominik (Dordrecht [u.a.] : Springer Science + Business Media B.V, 2024)

Purpose: 3D cell culture and hypoxia have been demonstrated to increase the therapeutic effects of mesenchymal stem/stromal cells (MSCs)-derived extracellular vesicles (EVs). In this study, a process for the production of ...
Low-cost sensor system for non-invasive monitoring of cell growth in disposable bioreactors

Reinecke, Tobias; Biechele, Philipp; Schulte, V.; Scheper, Thomas; Zimmermann, Stefan (Amsterdam : Elsevier, 2015)

To ensure productivity and product quality, the parameters of biotechnological processes need to be monitored. Along temperature or pH, one important parameter is the cell density in the culture medium. In this work, we ...
Process intensification in continuous flow biocatalysis by up and downstream processing strategies

Meyer, Lars-Erik; Hobisch, Markus; Kara, Selin (Amsterdam [u.a.] : Elsevier Science, 2022)

In this review, we focus on the holistic continuous enzymatic production and put special emphasis on process intensification by up- and downstream processing in continuous flow biocatalysis. After a brief introduction, we ...
Production of natural colorants by liquid fermentation with Chlorociboria aeruginascens and Laetiporus sulphureus and prospective applications

Zschätzsch, Marlen; Steudler, Susanne; Reinhardt, Olena; Bergmann, Pia; Ersoy, Franziska; Stange, Stephanie; Wagenführ, André; Walther, Thomas; Berger, Ralf Günter; Werner, Anett (Weinheim : Wiley-VCH, 2021)

The replacement of potentially hazardous synthetic dyes with natural dyes and pigments are of great interest for a sustainable economy. In order to obtain cost-efficient, environmentally friendly and competitive products, ...
Smart sustainable bottle (SSB) system for E. coli based recombinant protein production

Li, Zhaopeng; Carstensen, Bettina; Rinas, Ursula (London : BioMed Central Ltd., 2014)

Background: Recombinant proteins are usually required in laboratories interested in the protein but not in the production process itself. Thus, technical equipment which is easy to handle and straight forward protein ...

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Browsing by Subject "Bioreactors"

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