Auflistung nach Schlagwort "Biochemistry"

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  • Characterisation of a Recombinant Patchoulol Synthase Variant for Biocatalytic Production of Terpenes 
    Frister, Thore; Hartwig, Steffen; Alemdar, Semra; Schnatz, Katharina; Thöns, Laura; Scheper, Thomas; Beutel, Sascha (New York City, NY : Springer Humana Press Inc., 2015)
    The patchoulol synthase (PTS) is a multi-product sesquiterpene synthases which is the central enzyme for biosynthesis of patchouli essential oil in the patchouli plant. Sesquiterpene synthases catalyse the formation of ...
  • Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi 
    Szwalbe, Agniezka J.; Williams, Katherine; Song, Zhongshu; De Mattos-Shipley, Kate M.J.; Vincent, Jason L.; Bailey, Andrew M.; Willis, Christine L.; Cox, Russell J.; Simpson, Thomas J. (Cambridge : Royal Society of Chemistry, 2019)
    Two new dihydroxy-xanthone metabolites, agnestins A and B, were isolated from Paecilomyces variotii along with a number of related benzophenones and xanthones including monodictyphenone. The structures were elucidated by ...
  • Computational model of damage-induced growth in soft biological tissues considering the mechanobiology of healing 
    Gierig, Meike; Wriggers, Peter; Marino, Michele (Berlin ; Heidelberg ; New York, NY : Springer, 2021)
    Healing in soft biological tissues is a chain of events on different time and length scales. This work presents a computational framework to capture and couple important mechanical, chemical and biological aspects of ...
  • The cycloaspeptides: Uncovering a new model for methylated nonribosomal peptide biosynthesis 
    De Mattos-Shipley, Kate M.J.; Greco, Claudio; Heard, David M.; Hough, Gemma; Mulholland, Nicholas P.; Vincent, Jason L.; Micklefield, Jason; Simpson, Thomas J.; Willis, Christine L.; Cox, Russell J.; Bailey, Andrew M. (Cambridge : Royal Society of Chemistry, 2018)
    The cycloaspeptides are bioactive pentapeptides produced by various filamentous fungi, which have garnered interest from the agricultural industry due to the reported insecticidal activity of the minor metabolite, ...
  • Development of an aptamer-based affinity purification method for vascular endothelial growth factor 
    Lönne, Maren; Bolten, Svenja Nicolin; Lavrentieva, Antonina; Stahl, Frank; Scheper, Thomas; Walter, Johanna-Gabriela (Amsterdam : Elsevier B.V., 2015)
    Since aptamers bind their targets with high affinity and specificity, they are promising alternative ligands in protein affinity purification. As aptamers are chemically synthesized oligonucleotides, they can be easily ...
  • Eukaryotic Box C/D methylation machinery has two non-symmetric protein assembly sites 
    Höfler, Simone; Lukat, Peer; Blankenfeldt, Wulf; Carlomagno, Teresa ([London] : Macmillan Publishers Limited, part of Springer Nature, 2021)
    Box C/D ribonucleoprotein complexes are RNA-guided methyltransferases that methylate the ribose 2’-OH of RNA. The central ‘guide RNA’ has box C and D motifs at its ends, which are crucial for activity. Archaeal guide RNAs ...
  • The gene space of European mistletoe (Viscum album) 
    Schröder, Lucie; Hohnjec, Natalija; Senkler, Michael; Senkler, Jennifer; Küster, Helge; Braun, Hans-Peter (Oxford [u.a.] : Wiley-Blackwell, 2022)
    European mistletoe (Viscum album) is a hemiparasitic flowering plant that is known for its very special life cycle and extraordinary biochemical properties. Particularly, V. album has an unusual mode of cellular respiration ...
  • Heparin: role in protein purification and substitution with animal-component free material 
    Bolten, Svenja Nicolin; Rinas, Ursula; Scheper, Thomas (Heidelberg : Springer Verlag, 2018)
    Heparin is a highly sulfated polysaccharide which belongs to the family of glycosaminoglycans. It is involved in various important biological activities. The major biological purpose is the inhibition of the coagulation ...
  • Heterologe Produktion pilzlicher Maleidride enthüllt die kryptische Cyclisierung in ihrer Biosynthese 
    Williams, Katherine; Szwalbe, Agnieszka J.; Mulholland, Nicholas Phillip; Vincent, Jason Leigh; Bailey, Andy M.; Willis, Christine L.; Simpson, Thomas J.; Cox, Russell J. (Weinheim : Wiley-VCH, 2016)
    Die von Pilzen produzierten Maleidride sind eine wichtige Klasse bioaktiver Sekundarmetaboliten, die aus sieben-, acht- oder neungliedrigen Carbocyclen bestehen. Jeder Cyclus ist mit einem oder zwei anellierten ...
  • Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis 
    Williams, Katherine; Szwalbe, Agnieszka J.; Mulholland, Nicholas P.; Vincent, Jason L.; Bailey, Andrew M.; Willis, Christine L.; Simpson, Thomas J.; Cox, Russell J. (Weinheim : Wiley-VCH Verlag, 2016)
    Fungal maleidrides are an important family of bioactive secondary metabolites that consist of 7, 8, or 9-membered carbocycles with one or two fused maleic anhydride moieties. The biosynthesis of byssochlamic acid (a ...
  • Investigating the biosynthesis of Sch-642305 in the fungus : Phomopsis sp. CMU-LMA 
    Trenti, Francesco; Lebe, Karen E.; Adelin, Emilie; Ouazzani, Jamal; Schotte, Carsten; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2020)
    Sch-642305 is an unusual bicyclic 10-membered macrolide produced by the filamentous fungus Phomopsis sp. CMU-LMA for which no biosynthetic evidence exists. Here, we generate a draft genome sequence of the producing organism ...
  • L-galactono-1,4-lactone dehydrogenase (GLDH) forms part of three subcomplexes of mitochondrial complex I in Arabidopsis thaliana 
    Schertl, Peter; Sunderhaus, Stephanie; Klodmann, Jennifer; Gergoff Grozeff, Gustavo E.; Bartoli, Carlos G.; Braun, Hans-Peter (Bethesda, Md. : ASBMB Publications, 2012)
    L-Galactono-1,4-lactone dehydrogenase (GLDH) catalyzes the terminal step of the Smirnoff-Wheeler pathway for vitamin C (L-ascorbate) biosynthesis in plants. A GLDH in gel activity assay was developed to biochemically ...
  • Membrane chaperoning by members of the PspA/IM30 protein family. 
    Thurotte, Adrien; Brüser, Thomas; Mascher, Thorsten; Schneider, Dirk (London : Informa UK Limited, 2017)
    PspA, IM30 (Vipp1) and LiaH, which all belong to the PspA/IM30 protein family, form high molecular weight oligomeric structures. For all proteins membrane binding and protection of the membrane structure and integrity has ...
  • Orange, red, yellow: Biosynthesis of azaphilone pigments in Monascus fungi 
    Chen, Wanping; Chen, Runfa; Liu, Qingpei; He, Yi; He, Kun; Ding, Xiaoli; Kang, Lijing; Guo, Xiaoxiao; Xie, Nana; Zhou, Youxiang; Lu, Yuanyuan; Cox, Russell J.; Molnár, Istvan; Li, Mu; Shao, Yanchun; Chen, Fusheng (Cambridge : Royal Society of Chemistry, 2017)
    Monascus azaphilone pigments (MonAzPs) are very widely used as food colorants, but their biosynthetic pathway has remained poorly characterized for more than half a century. In this study, the individual steps of MonAzPs ...
  • Oxidative steps during the biosynthesis of squalestatin S1 
    Lebe, Karen E.; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2018)
    The squalestatins are a class of highly complex fungal metabolites which are potent inhibitors of squalene synthase with potential use in the control of cholesterol biosynthesis. Little is known of the chemical steps ...
  • Post-Cyclization Skeletal Rearrangements in Plant Triterpenoid Biosynthesis by a Pair of Branchpoint Isomerases 
    Chuang, Ling; Liu, Shenyu; Franke, Jakob (Washington, DC : ACS Publications, 2023)
    Triterpenoids possess potent biological activities, but their polycyclic skeletons are challenging to synthesize. The skeletal diversity of triterpenoids in plants is generated by oxidosqualene cyclases based on epoxide-triggered ...
  • Single organelle function and organization as estimated from Arabidopsis mitochondrial proteomics 
    Fuchs, Philippe; Rugen, Nils; Carrie, Chris; Elsässer, Marlene; Finkemeier, Iris; Giese, Jonas; Hildebrandt, Tatjana M.; Kühn, Kristina; Maurino, Veronica G.; Ruberti, Cristina; Schallenberg-Rüdinger, Mareike; Steinbeck, Janina; Braun, Hans-Peter; Eubel, Holger; Meyer, Etienne H.; Müller-Schüssele, Stefanie J.; Schwarzländer, Markus (Oxford [u.a.] : Wiley-Blackwell, 2020)
    Mitochondria host vital cellular functions, including oxidative phosphorylation and co-factor biosynthesis, which are reflected in their proteome. At the cellular level plant mitochondria are organized into hundreds of ...
  • The sporothriolides. A new biosynthetic family of fungal secondary metabolites 
    Tian, Dong-Song; Kuhnert, Eric; Ouazzani, Jamal; Wibberg, Daniel; Kalinowski, Jörn; Cox, Russell J. (Cambridge : RSC, 2020)
    The biosynthetic gene cluster of the antifungal metabolite sporothriolide 1 was identified from three producing ascomycetes: Hypomontagnella monticulosa MUCL 546, H. spongiphila CLL 205 and H. submonticulosa DAOMC 242471. ...
  • Supramolecular structure of the mitochondrial oxidative phosphorylation system 
    Boekema, Egbert J.; Braun, Hans-Peter (Bethesda, Md. : ASBMB Publications, 2007)
    The protein complexes of the mitochondrial oxidative phosphorylation system were recently reported to form supramolecular assemblies termed respiratory supercomplexes or respirasomes. These supercomplexes are considered ...
  • Total biosynthesis of fungal tetraketide pyrones 
    Sun, Yunlong; Tian, Dongsong; Kuhnert, Eric; Le Goff, Geraldine; Arcile, Guillaume; Ouazzani, Jamal; Cox, Russell J. (Cambridge : Soc., 2023)
    Fungal tetraketide pyrones possess important and potent bioactivities, but their detailed biosynthetic pathways are unknown and synthetic routes to their production are lengthy. Here we investigated the fungal pathways to ...