Browsing by Subject "Anti-Bacterial Agents"

Browsing by Subject "Anti-Bacterial Agents"

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  • Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP 
    Schumacher, Maria A.; Wörmann, Mirka E.; Henderson, Max; Salinas, Raul; Latoscha, Andreas; Al-Bassam, Mahmoud M.; Singh, Kumar Siddharth; Barclay, Elaine; Gunka, Katrin; Tschowri, Natalia ([London] : Nature Publishing Group UK, 2022)
    Streptomyces are our principal source of antibiotics, which they generate concomitant with a complex developmental transition from vegetative hyphae to spores. c-di-GMP acts as a linchpin in this transition by binding and ...
  • Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens 
    Pinkert, Lukas; Lai, Yi-Hui; Peukert, Carsten; Hotop, Sven-Kevin; Karge, Bianka; Schulze, Lara Marie; Grunenberg, Jörg; Brönstrup, Mark (Washington, DC : ACS, 2021)
    The development of novel drugs against Gram-negative bacteria represents an urgent medical need. To overcome their outer cell membrane, we synthesized conjugates of antibiotics and artificial siderophores based on the MECAM ...
  • The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition 
    Koller, Timm O.; Scheid, Ullrich; Kösel, Teresa; Herrmann, Jennifer; Krug, Daniel; Boshoff, Helena I. M.; Beckert, Bertrand; Evans, Joanna C.; Schlemmer, Jan; Sloan, Becky; Weiner, Danielle M.; Via, Laura E.; Moosa, Atica; Ioerger, Thomas R.; Graf, Michael; Zinshteyn, Boris; Abdelshahid, Maha; Nguyen, Fabian; Arenz, Stefan; Gille, Franziska; Siebke, Maik; Seedorf, Tim; Plettenburg, Oliver; Green, Rachel; Warnke, Anna-Luisa; Ullrich, Joachim; Warrass, Ralf; Barry, Clifton E.; Warner, Digby F.; Mizrahi, Valerie; Kirschning, Andreas; Wilson, Daniel N.; Müller, Rolf (Washington, DC : ACS Publications, 2023)
    Resistance of bacterial pathogens against antibiotics is declared by WHO as a major global health threat. As novel antibacterial agents are urgently needed, we re-assessed the broad-spectrum myxobacterial antibiotic ...
  • Silver nanoparticle-doped zirconia capillaries for enhanced bacterial filtration 
    Wehling, Julia; Köser, Jan; Lindner, Patrick; Lüder, Christian; Beutel, Sascha; Kroll, Stephen; Rezwan, Kurosch (London : Elsevier Ltd., 2014)
    Membrane clogging and biofilm formation are the most serious problems during water filtration. Silver nanoparticle (Agnano) coatings on filtration membranes can prevent bacterial adhesion and the initiation of biofilm ...
  • Trojan Horse Siderophore Conjugates Induce Pseudomonas aeruginosa Suicide and Qualify the TonB Protein as a Novel Antibiotic Target 
    Peukert, Carsten; Gasser, Véronique; Orth, Till; Fritsch, Sarah; Normant, Vincent; Cunrath, Olivier; Schalk, Isabelle J.; Brönstrup, Mark (Washington, DC : ACS, 2023)
    Rising infection rates with multidrug-resistant pathogens calls for antibiotics with novel modes of action. Herein, we identify the inner membrane protein TonB, a motor of active uptake in Gram-negative bacteria, as a novel ...
  • UV/Vis light induced degradation of oxytetracycline hydrochloride mediated by Co-TiO2 nanoparticles 
    Akel, Soukaina; Boughaled, Redouan; Dillert, Ralf; Azzouzi, Mohamed El; Bahnemann, Detlef W. (Basel : MDPI AG, 2020)
    Pharmaceuticals, especially antibiotics, constitute an important group of aquatic contaminants given their environmental impact. Specifically, tetracycline antibiotics (TCs) are produced in great amounts for the treatment ...