Auflistung nach Schlagwort "Amyloid"

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  • Binding of a Pyrene-Based Fluorescent Amyloid Ligand to Transthyretin: A Combined Crystallographic and Molecular Dynamics Study 
    Thi Minh, Nghia Nguyen; Begum, Afshan; Zhang, Jun; Leira, Petter; Todarwal, Yogesh; Linares, Mathieu; Norman, Patrick; Derbyshire, Dean; von Castelmur, Eleonore; Lindgren, Mikael; Hammarström, Per; König, Carolin (Washington, DC : Soc., 2023)
    Misfolding and aggregation of transthyretin (TTR) cause several amyloid diseases. Besides being an amyloidogenic protein, TTR has an affinity for bicyclic small-molecule ligands in its thyroxine (T4) binding site. One class ...
  • Understanding fluorescent amyloid biomarkers by computational chemistry 
    Nguyen, Thi Minh Nghia (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2023)
    Protein misfolding diseases, including neurodegenerative disorders like Alzheimer’s disease, are characterized by the involvement of amyloid aggregation, which emphasizes the need for molecular biomarkers for effective ...