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Browsing by Subject "Alkylation"

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Investigation of chain-length selection by the tenellin iterative highly-reducing polyketide synthase

Schmidt, Katharina; Cox, Russell J. (London : RSC Publishing, 2024)

The programming of widely distributed iterative fungal hr-PKS is mysterious, yet it is central for generating polyketide natural product diversity by controlling the chain length, β-processing level and methylation patterns ...
Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase

Yang, Xiao-Long; Friedrich, Steffen; Yin, Sen; Piech, Oliver; Williams, Katherine; Simpson, Thomas J.; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2019)

Exchange of 32 different sub-fragments of the C-methyltransferase (C-MeT), pseudo-ketoreductase (ΨKR) and ketoreductase (KR) catalytic domains of the tenellin iterative Type I polyketide synthase non ribosomal peptide ...
Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming

Roberts, Douglas M.; Bartel, Christoph; Scott, Alan; Ivison, David; Simpson, Thomas J.; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2017)

A cis-acting enoyl reductase (ER) catalytic domain was isolated from a fungal highly reducing iterative polyketide synthase (HR-iPKS) for the first time and studied in vitro. The ER from the squalestatin tetraketide synthase ...
Sulfonium Acids Loaded onto an Unusual Thiotemplate Assembly Line Construct the Cyclopropanol Warhead of a Burkholderia Virulence Factor

Trottmann, Felix; Ishida, Keishi; Franke, Jakob; Stanišić, Aleksa; Ishida-Ito, Mie; Kries, Hajo; Pohnert, Georg; Hertweck, Christian (Weinheim : Wiley-VCH, 2020)

Pathogenic bacteria of the Burkholderia pseudomallei group cause severe infectious diseases such as glanders and melioidosis. Malleicyprols were identified as important bacterial virulence factors, yet the biosynthetic ...

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Browsing by Subject "Alkylation"

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