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Auflistung nach Schlagwort "biosynthesis"

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Probing cytochrome c in living mitochondria with surface-enhanced Raman spectroscopy

Brazhe, Nadezda A.; Evlyukhin, Andrey B.; Goodilin, Eugene A.; Semenova, Anna A.; Novikov, Sergey M.; Bozhevolnyi, Sergey I.; Chichkov, Boris; Sarycheva, Asya S.; Baizhumanov, Adil A.; Nikelshparg, Evelina I.; Deev, Leonid I.; Maksimov, Eugene G.; Maksimov, Georgy V.; Sosnovtseva, Olga (London : Nature Publishing Group, 2015)

Selective study of the electron transport chain components in living mitochondria is essential for fundamental biophysical research and for the development of new medical diagnostic methods. However, many important details ...
PvdM of fluorescent pseudomonads is required for the oxidation of ferribactin by PvdP in periplasmic pyoverdine maturation

Sugue, Michael-Frederick; Burdur, Ali Nazmi; Ringel, Michael T.; Dräger, Gerald; Brüser, Thomas (Bethesda, Md. : ASBMB Publications, 2022)

Fluorescent pseudomonads such as Pseudomonas aeruginosa or Pseudomonas fluorescens produce pyoverdine siderophores that ensure iron-supply in iron-limited environments. After its synthesis in the cytoplasm, the nonfluorescent ...
PvdO is required for the oxidation of dihydropyoverdine as the last step of fluorophore formation in Pseudomonas fluorescensDihydropyoverdine oxidation by PvdO

Ringel, Michael T.; Dräger, Gerald; Brüser, Thomas (Bethesda, Md. : ASBMB Publications, 2018)

Pyoverdines are important siderophores that guarantee iron supply to important pathogenic and non-pathogenic pseudomonads in host habitats. A key characteristic of all pyoverdines is the fluorescent dihydroxyquinoline group ...
Quantification and fatty acid profiles of sulfolipids in two halophytes and a glycophyte grown under different salt concentrations

Ramani, Balasubramanian; Zorn, Holger; Papenbrock, Jutta (Berlin : De Gruyter, 2004)

This study was aimed at understanding the role of sulfolipids in salt tolerance mechanisms of the halophytes Aster tripolium L., Compositae, and Sesuvium portulacastrum L., Aizoaceae, and of the glycophyte Arabidopsis ...
Rational engineering of an iterative polyketide synthase

Schmidt, Katharina (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2024)

The focus of the presented work is the engineering of polyketide-derived natural products in different stages of their biosynthesis. Within this context, one project centres on the engineering of a polyketide synthase ...
Side effects of chaperone gene co-expression in recombinant protein production

Martínez-Alonso, Monica; García-Fruitós, Elena; Ferrer-Miralles, Neus; Rinas, Ursula; Villaverde, Antonio (London : BioMed Central Ltd., 2010)

Insufficient availability of molecular chaperones is observed as a major bottleneck for proper protein folding in recombinant protein production. Therefore, co-production of selected sets of cell chaperones along with ...
Smart sustainable bottle (SSB) system for E. coli based recombinant protein production

Li, Zhaopeng; Carstensen, Bettina; Rinas, Ursula (London : BioMed Central Ltd., 2014)

Background: Recombinant proteins are usually required in laboratories interested in the protein but not in the production process itself. Thus, technical equipment which is easy to handle and straight forward protein ...
Stereochemical and Biosynthetic Rationalisation of the Tropolone Sesquiterpenoids

Li, Lei; Cox, Russell J. (Basel : MDPI, 2022)

This review summarises the known structures, biological activities, and biosynthetic pathways of the tropolone sesquiterpenoid family of fungal secondary metabolites. Synthesis of this knowledge allows likely structural ...
Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi

Greco, Claudio; de Mattos-Shipley, Kate; Bailey, Andrew M.; Mulholland, Nicholas P.; Vincent, Jason L.; Willis, Christine L.; Cox, Russell J.; Simpson, Thomas J. (Cambridge : Royal Society of Chemistry, 2019)

Three novel dimeric xanthones, cryptosporioptides A–C were isolated from Cryptosporiopsis sp. 8999 and their structures elucidated. Methylation of cryptosporioptide A gave a methyl ester with identical NMR data to ...
Studies with lysine N6-hydroxylase. Effect of a mutation in the assumed FAD binding site on coenzyme affinities and on lysine hydroxylating activity

Stehr, Matthias; Smau, Liliana; Singh, Mahavir; Seth, Oliver; Macheroux, Peter; Ghisla, Sandro; Diekmann, Hans (Berlin : De Gruyter, 1999)

The proposed FAD binding site of L-lysine N6-hydroxylase (EC 1.14.13.99) exhibits an unusual proline in a position where a highly conserved glycine is found in other FAD dependent hydroxylases. We have studied the role of ...
Synthetic Biology Driven Biosynthesis of Unnatural Tropolone Sesquiterpenoids

Schotte, Carsten; Li, Lei; Wibberg, Daniel; Kalinowski, Jörn; Cox, Russell J. (Weinheim : Wiley-VCH Verl., 2020)

Tropolone sesquiterpenoids (TS) are an intriguing family of biologically active fungal meroterpenoids that arise through a unique intermolecular hetero Diels–Alder (hDA) reaction between humulene and tropolones. Here, we ...
Understanding and engineering the biosynthesis of tropolone sesquiterpenoids in fungi

Schotte, Carsten (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2021)

Tropolone sesquiterpenoids (TS) are meroterpenoid natural products that share the conserved structural feature of a polyketide-derived tropolone nucleus connected to a humulene-derived macrocycle via a bridging dihydropyran ...
Understanding and Engineering the Stereoselectivity of Humulene Synthase

Schotte, Carsten; Lukat, Peer; Deuschmann, Adrian; Blankenfeldt, Wulf; Cox, Russell J. (Weinheim : Wiley-VCH, 2021)

The non-canonical terpene cyclase AsR6 is responsible for the formation of 2E,6E,9E-humulene during the biosynthesis of the tropolone sesquiterpenoid (TS) xenovulene A. The structures of unliganded AsR6 and of AsR6 in ...
Understanding and exploiting fungal PKS-NRPS biosynthesis in Pyricularia and Magnaporthe species

Hantke, Verena (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2019)

The fungus Pyricularia oryzae is a major pathogen of rice (Oryzae sativa) that causes substantial loss of yields every year. Remarkably, certain rice strains carrying the Pi33 gene are resistant to strains of P. oryzae ...
Understanding and Exploiting the Fungal Biosynthesis of Bisorbicillinoids and Terrein

Kahlert, Lukas (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2021)

The biosynthetic pathways towards the polyketides terrein and (dimeric) sorbicillinoids, such as the Diels-Alder derived bisorbicillinol, were investigated. Both pathways were reconstituted step by step in Aspergillus ...
Understanding, engineering and chemical modification of pyrichalasin H biosynthesis from Magnaporthe grisea NI980

Wang, Chongqing (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2020)

Pyrichalasin H 65 belongs to the cytochalasan family of fungal natural products, and is the major phytotoxic metabolite produced by the fungal plant pathogen Magnaporthe grisea NI980. In a combined chemical and genetic ...
Virus-like particle production with yeast: Ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the Hepatitis B surface antigen

Lünsdorf, Heinrich; Gurramkonda, Chandrasekhar; Adnan, Ahmad; Khanna, Navin; Rinas, Ursula (London : BioMed Central Ltd., 2011)

Background: A protective immune response against Hepatitis B infection can be obtained through the administration of a single viral polypeptide, the Hepatitis B surface antigen (HBsAg). Thus, the Hepatitis B vaccine is ...
Withanolides: Elucidating steroidal lactone biosynthesis in Nightshades

Stein, Annika (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2022)

Withania somnifera (Solanaceae) is well known in ayurvedic medicine as a strengthening tonic for various medical purposes. Its effects are mainly due to withanolides, a class of steroidal lactones with diverse oxidation ...

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