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EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival

Jara-Avaca, Monica; Kempf, Henning; Rückert, Michael; Robles-Diaz, Diana; Franke, Annika; de la Roche, Jeanne; Fischer, Martin; Malan, Daniela; Sasse, Philipp; Solodenko, Wladimir; Dräger, Gerald; Kirschning, Andreas; Martin, Ulrich; Zweigerdt, Robert (New York, NY : Springer, 2017)

Subtype-specific human cardiomyocytes (CMs) are valuable for basic and applied research. Induction of cardiomyogenesis and enrichment of nodal-like CMs was described for mouse pluripotent stem cells (mPSCs) in response to ...
Effects of soil pre-treatment with Basamid® granules, Brassica juncea, Raphanus sativus, and tagetes patula on bacterial and fungal communities at two apple replant disease sites

Yim, Bunlong; Nitt, Heike; Wrede, Andreas; Jacquiod, Samuel; Sørensen, Søren J.; Winkelmann, Traud; Smalla, Kornelia (Lausanne : Frontiers Media S.A., 2017)

Nurseries producing apple and rose rootstock plants, apple orchards as well as rose production often experience replanting problems after several cultivations at the same site when a chemical soil disinfectant is not ...
Enzymes: The two roles of complex iii in plants

Braun, Hans-Peter (Cambridge : eLife Sciences Publications, 2021)

Atomic structures of mitochondrial enzyme complexes in plants are shedding light on their multiple functions.
Ethical issues in consumer genome sequencing: Use of consumers' samples and data

Niemiec, Emilia; Howard, Heidi Carmen (Amsterdam : Elsevier, 2016)

High throughput approaches such as whole genome sequencing (WGS) and whole exome sequencing (WES) create an unprecedented amount of data providing powerful resources for clinical care and research. Recently, WGS and WES ...
Evaluation of the biological tolerability of the starch-based medical device 4DryField® PH in vitro and in vivo a rat model

Poehnert, Daniel; Abbas, Mahmoud; Maegel, Lavinia; Sambale, Franziska; Lavrentieva, Antonina; Kreipe, Hans-Heinrich; Klempnauer, Jürgen; Winny, Markus (London : SAGE Publications Ltd., 2015)

Purpose To evaluate in vitro cytotoxicity/biocompatibility as well as in vivo tolerability of the novel polysaccharide 4DryField® PH, certified for haemostasis and adhesion prevention. Methods In vitro cytotoxicity/viability ...
Experimental microbial alteration and Fe mobilization from basaltic rocks of the ICDP HSDP2 drill core, Hilo, Hawaii

Stranghoener, Marius; Schippers, Axel; Dultz, Stefan; Behrens, Harald (Lausanne : Frontiers Media S.A., 2018)

The interaction of a single bacterial species (Burkholderia fungorum) with basaltic rocks from the ICDP HSDP2 drill core and synthetic basaltic glasses was investigated in batch laboratory experiments to better understand ...
Extended darkness induces internal turnover of glucosinolates in Arabidopsis thaliana leaves

Brandt, Saskia; Fachinger, Sara; Tohge, Takayuki; Fernie, Alisdair R.; Braun, Hans-Peter; Hildebrandt, Tatjana M. (San Francisco, CA : Public Library of Science, 2018)

Prolonged darkness leads to carbohydrate starvation, and as a consequence plants degrade proteins and lipids to oxidize amino acids and fatty acids as alternative substrates for mitochondrial ATP production. We investigated, ...
Factors determining microbial colonization of liquid nitrogen storage tanks used for archiving biological samples

Bajerski, F.; Bürger, A.; Glasmacher, B.; Keller, E.R.J.; Müller, K.; Mühldorfer, K.; Nagel, M.; Rüdel, H.; Müller, T.; Schenkel, J.; Overmann, J. (Heidelberg : Springer Verlag, 2020)

The availability of bioresources is a precondition for life science research, medical applications, and diagnostics, but requires a dedicated quality management to guarantee reliable and safe storage. Anecdotal reports of ...
Fate of the UPR marker protein Kar2/Bip and autophagic processes in fed-batch cultures of secretory insulin precursor producing Pichia pastoris

Roth, Gustavo; Vanz, Ana Leticia; Lünsdorf, Heinrich; Nimtz, Manfred; Rinas, Ursula (London : BioMed Central Ltd., 2018)

Background: Secretory recombinant protein production with Pichia (syn. Komagataella) pastoris is commonly associated with the induction of an unfolded protein response (UPR) usually apparent through increased intracellular ...
Femtosecond laser induced step-like structures inside transparent hydrogel due to laser induced threshold reduction

Saerchen, Emanuel; Liedtke-Gruener, Susann; Kopp, Maximilian; Heisterkamp, Alexander; Lubatschowski, Holger; Ripken, Tammo (San Francisco, CA : Public Library of Science (PLoS), 2019)

In the area of laser material processing, versatile applications for cutting glasses and transparent polymers exist. However, parasitic effects such as the creation of step-like structures appear when laser cutting inside ...
Flow rate dependent continuous hydrolysis of protein isolates

Sewczyk, Tim; Hoog Antink, Marieke; Maas, Michael; Kroll, Stephen; Beutel, Sascha (Heidelberg : Springer Verlag, 2018)

Food protein hydrolysates are often produced in unspecific industrial batch processes. The hydrolysates composition underlies process-related fluctuations and therefore the obtained peptide fingerprint and bioactive ...
Healthcare providers' perception of the referral system in maternal care facilities in Aceh, Indonesia: A cross-sectional study

Diba, Farah; Ichsan, Ichsan; Muhsin, Muhsin; Marthoenis, Marthoenis; Sofyan, Hizir; Andalas, Mohammad; Monfared, Ida; Richert, Katharina; Kaplan, Lennart; Rogge, Lisa; Doria, Siobhan; Samadi, Samadi; Vollmer, Sebastian (London : BMJ Publishing Group, 2019)

Objectives Our study investigates the barriers perceived by staff in the referral systems in maternal healthcare facilities across Aceh province in Indonesia. Design With a cross-sectional approach, two sets of surveys ...
High intensity high volume interval training improves endurance performance and induces a nearly complete slow-to-fast fiber transformation on the mRNA level

Eigendorf, Julian; May, Marcus; Friedrich, Jan; Engeli, Stefan; Maassen, Norbert; Gros, Gerolf; Meissner, Joachim D. (Lausanne : Frontiers Media S.A., 2018)

We present here a longitudinal study determining the effects of two 3 week-periods of high intensity high volume interval training (HIHVT) (90 intervals of 6 s cycling at 250% maximum power, Pmax/24 s) on a cycle ergometer. ...
Highly variable pharmacokinetics of tyramine in humans and polymorphisms in OCT1, CYP2D6, and MAO-A

Rafehi, Muhammed; Faltraco, Frank; Matthaei, Johannes; Prukop, Thomas; Jensen, Ole; Grytzmann, Aileen; Blome, Felix G.; Berger, Ralf Günter; Krings, Ulrich; Vormfelde, Stefan V.; Tzvetkov, Mladen V.; Brockmöller, Jürgen (Lausanne : Frontiers Media S.A., 2019)

Tyramine, formed by the decarboxylation of tyrosine, is a natural constituent of numerous food products. As an indirect sympathomimetic, it can have potentially dangerous hypertensive effects. In vitro data indicated that ...
Human umbilical cord-derived mesenchymal stem cells utilise activin-A to suppress interferon-gamma production by natural killer cells

Chatterjee, Debanjana; Marquardt, Nicole; Tufa, Dejene Milkessa; Hatlapatka, Tim; Hass, Ralf; Kasper, Cornelia; Kaisenberg, Constantin von; Schmidt, Reinhold Ernst; Jacobs, Roland (Lausanne : Frontiers Research Foundation, 2014)

Following allogeneic hematopoietic stem cell transplantation (HSCT), interferon (IFN)-γ levels in the recipient's body can strongly influence the clinical outcome. Human umbilical cord-derived mesenchymal stem cells (UC-MSCs) ...
Hydrogel-based microfluidics for vascular tissue engineering

Koroleva, Anastasia; Deiwick, Andrea; Nguyen, Alexander; Narayan, Roger; Shpichka, Anastasia; Kufelt, Olga; Kiyan, Roman; Bagratashvili, Victor N.; Timashev, Peter; Scheper, Thomas; Chichkov, Boris (Berlin : De Gruyter, 2016)

In this work, we have explored 3-D co-culture of vasculogenic cells within a synthetically modified fibrin hydrogel. Fibrinogen was covalently linked with PEG-NHS in order to improve its degradability resistance and ...
Immiscible hydrous Fe-Ca-P melt and the origin of iron oxide-apatite ore deposits

Hou, Tong; Charlier, Bernard; Holtz, Francois; Veksler, Ilya; Zhang, Zhaochong; Thomas, Rainer; Namur, Olivier (London : Springer Nature, 2018)

The origin of iron oxide-apatite deposits is controversial. Silicate liquid immiscibility and separation of an iron-rich melt has been invoked, but Fe-Ca-P-rich and Si-poor melts similar in composition to the ore have never ...
Influence of combined functional resistance and endurance exercise over 12 weeks on matrix metalloproteinase-2 serum concentration in persons with relapsing-remitting multiple sclerosis-a community-based randomized controlled trial

Proschinger, Sebastian; Joisten, Niklas; Rademacher, Annette; Schlagheck, Marit L.; Walzik, David; Metcalfe, Alan J.; Oberste, Max; Warnke, Clemens; Bloch, Wilhelm; Schenk, Alexander; Bansi, Jens; Zimmer, Philipp (London : BioMed Central Ltd., 2019)

Background: The relevance of regular moderate to intense exercise for ameliorating psychomotor symptoms in persons with multiple sclerosis (pwMS) is becoming increasingly evident. Over the last two decades, emerging evidence ...
Innovation in medicine through degeneration in law? A critical perspective on the Medical Innovation Bill

Hoppe, Nils; Miola, José (London : SAGE Publications Ltd., 2014)

The current debate surrounding the Medical Innovation Bill purports to be aimed at improving the normative framework to the extent that innovation is more likely. A closer look at the mechanisms of the proposed legislation ...
Interaction mechanisms of cavitation bubbles induced by spatially and temporally separated fs-laser pulses

Tinne, Nadine; Kaune, Brigitte; Krüger, Alexander; Ripken, Tammo (San Francisco, CA : Public Library of Science (PLoS), 2014)

The emerging use of femtosecond lasers with high repetition rates in the MHz regime together with limited scan speed implies possible mutual optical and dynamical interaction effects of the individual cutting spots. In ...

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