Browsing by Author "ae2af464-2b65-4f9c-9a13-ed477d60d035"

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Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells

Kempf, Henning; Olmer, Ruth; Haase, Alexandra; Franke, Annika; Bolesani, Emiliano; Schwanke, Kristin; Robles-Diaz, Diana; Coffee, Michelle; Goehring, Gudrun; Draeger, Gerald; Poetz, Oliver; Joos, Thomas; Martinez-Hackert, Erik; Haverich, Axel; Buettner, Falk F.R. (London : Nature Publishing Group, 2016)

In vitro differentiation of human pluripotent stem cells (hPSCs) recapitulates early aspects of human embryogenesis, but the underlying processes are poorly understood and controlled. Here we show that modulating the bulk ...
Herstellung von humanen induzierten pluripotenten Stammzellen (iPS-Zellen) aus Nabelschnurblut

Haase, Alexandra (Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2011)

[no abstract]
High Density Bioprocessing of Human Pluripotent Stem Cells by Metabolic Control and in Silico Modeling

Manstein, Felix; Ullmann, Kevin; Kropp, Christina; Halloin, Caroline; Triebert, Wiebke; Franke, Annika; Farr, Clara-Milena; Sahabian, Anais; Haase, Alexandra; Breitkreuz, Yannik; Peitz, Michael; Brüstle, Oliver; Kalies, Stefan; Martin, Ulrich; Olmer, Ruth; Zweigerdt, Robert (Oxford : Oxford University Press, 2021)

To harness the full potential of human pluripotent stem cells (hPSCs) we combined instrumented stirred tank bioreactor (STBR) technology with the power of in silico process modeling to overcome substantial, hPSC-specific ...

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