Inadequate vascularization leading to insufficient oxygen and nutrient supply in deeper layers of bioartificial tissues remains a limitation in current tissue engineering approaches to which prevascularization offers a ...

State-of-the-art treatment for sensorineural hearing loss is based on electrical stimulation of residual spiral ganglion neurons (SGNs) with cochlear implants (CIs). Due to the anatomical gap between the electrode contacts ...

The objective of this study is to evaluate the suitability of a mouse middle ear model for testing ossicular replacement materials. Twenty-four BALB/c mice are implanted with the bioglass-ceramic Bioverit® II which is ...

The removal of the cochlear implant (CI), which in some cases is without alternative, is still an act of simple pulling, not only causing harm for the patient by damaging tissue but also making reimplantation more difficult. ...

In this tutorial review we present the process of the development of functional implants using mesoporous silica. The different steps from chemical synthesis and physicochemical characterization followed by in vitro testing ...

We have introduced nanoporous silica as a novel biomaterial. Nanoporous silica is non-toxic and biocompatible. It provides a high surface area and pore volume, uniform and tunable pore sizes and the possibility for chemical ...

A pH-sensitive stimulus-response system for controlled drug release was prepared by modifying nanoporous silica nanoparticles (NPSNPs) with poly(4-vinylpyridine) using a bismaleimide as linker. At physiological pH values, ...