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Analysis of the dominant mutation N188T of human connexin46 (hCx46) using concatenation and molecular dynamics simulation

Schadzek, Patrik; Stahl, Yannick; Preller, Matthias; Ngezahayo, Anaclet (Chichester : John Wiley and Sons Ltd, 2019)

Connexins (Cx) are proteins that form cell‐to‐cell gap junction channels. A mutation at position 188 in the second extracellular loop (E2) domain of hCx46 has been linked to an autosomal dominant zonular pulverulent cataract. ...
Concatenation of human connexin26 (hCx26) and human connexin46 (hCx46) for the analysis of heteromeric gap junction hemichannels and heterotypic gap junction channels

Schadzek, Patrick; Hermes, Doris; Stahl, Yannick; Dilger, Nadine; Ngezahayo, Anaclet (Basel : MDPI AG, 2018)

Gap junction channels and hemichannels formed by concatenated connexins were analyzed. Monomeric (hCx26, hCx46), homodimeric (hCx46-hCx46, hCx26-hCx26), and heterodimeric (hCx26-hCx46, hCx46-hCx26) constructs, coupled to ...

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