Auflistung nach Autor/in "3161754a-3534-4733-a70a-4ff4140d815f"

Auflistung nach Autor/in "3161754a-3534-4733-a70a-4ff4140d815f"

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  • Histone chaperone exploits intrinsic disorder to switch acetylation specificity 
    Danilenko, Nataliya; Lercher, Lukas; Kirkpatrick, John; Gabel, Frank; Codutti, Luca; Carlomagno, Teresa (London : Nature Publishing Group, 2019)
    Histones, the principal protein components of chromatin, contain long disordered sequences, which are extensively post-translationally modified. Although histone chaperones are known to control both the activity and ...
  • An NMR Study of a 300-kDa AAA+ Unfoldase 
    Krüger, Georg; Kirkpatrick, John; Mahieu, Emilie; Franzetti, Bruno; Gabel, Frank; Carlomagno, Teresa (Amsterdam [u.a.] : Elsevier, 2023)
    AAA+ ATPases are ubiquitous hexameric unfoldases acting in cellular protein quality control. In complex with proteases, they form protein degradation machinery (the proteasome) in both archaea and eukaryotes. Here, we use ...
  • Observing Protein Degradation by the PAN-20S Proteasome by Time-Resolved Neutron Scattering 
    Mahieu, Emilie; Covès, Jaques; Krüger, Georg; Martel, Anne; Moulin, Martine; Carl, Nico; Härtlein, Michael; Carlomagno, Teresa; Franzetti, Bruno; Gabel, Frank (Cambridge, MA : Cell Press, 2020)
    The proteasome is a key player of regulated protein degradation in all kingdoms of life. Although recent atomic structures have provided snapshots on a number of conformations, data on substrate states and populations ...
  • A real-time analysis of GFP unfolding by the AAA+ unfoldase PAN 
    Krüger, Georg; Kirkpatrick, John; Mahieu, Emilie; Franzetti, Bruno; Gabel, Frank; Carlomagno, Teresa (Amsterdam [u.a.] : Elsevier, 2023)
    Protein quality control systems are essential to maintain a healthy proteome. They often consist of an unfoldase unit, typically an AAA+ ATPase, coupled with a protease unit. In all kingdoms of life, they function to ...