dc.identifier.uri |
http://dx.doi.org/10.15488/811 |
|
dc.identifier.uri |
http://www.repo.uni-hannover.de/handle/123456789/835 |
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dc.contributor.author |
Guetzoyan, Lucie
|
|
dc.contributor.author |
Ingham, Richard J.
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|
dc.contributor.author |
Nikbin, Nikzad
|
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dc.contributor.author |
Rossignol, Julien
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dc.contributor.author |
Wolling, Michael
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dc.contributor.author |
Baumert, Mark
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dc.contributor.author |
Burgess-Brown, Nicola A.
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dc.contributor.author |
Strain-Damerell, Claire M.
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dc.contributor.author |
Shrestha, Leela
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dc.contributor.author |
Brennan, Paul E.
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dc.contributor.author |
Fedorov, Oleg
|
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dc.contributor.author |
Knapp, Stefan
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dc.contributor.author |
Ley, Steven V.
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dc.date.accessioned |
2016-12-06T10:06:44Z |
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dc.date.available |
2016-12-06T10:06:44Z |
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dc.date.issued |
2014 |
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dc.identifier.citation |
Guetzoyan, Lucie; Ingham, Richard J.; Nikbin, Nikzad; Rossignol, Julien; Wolling, Michael et al.: Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography. In: MedChemComm 5 (2014), Nr. 4, S. 540-546. DOI: http://dx.doi.org/10.1039/C4MD00007B |
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dc.description.abstract |
A combination of conventional organic synthesis, remotely monitored flow synthesis and bioassay platforms, were used for the evaluation of novel inhibitors targeting bromodomains outside the well-studied bromodomain and extra terminal (BET) family, here exemplified by activity measurements on the bromodomain of BRD9 protein, a component of some tissue-specific SWi/SNF chromatin remodelling complexes. The Frontal Affinity Chromatography combined with Mass Spectrometry (FAC-MS) method proved to be reliable and results correlated well with an independent thermal shift assay. |
eng |
dc.description.sponsorship |
EPSRC/EP/F069685/1 |
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dc.description.sponsorship |
Novartis |
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dc.description.sponsorship |
BP Endowment |
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dc.language.iso |
eng |
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dc.publisher |
Cambridge : Royal Society of Chemistry |
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dc.relation.ispartofseries |
MedChemComm 5 (2014), Nr. 4 |
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dc.rights |
Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
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dc.subject |
Biochemie |
eng |
dc.subject |
FAC-MS |
eng |
dc.subject |
Frontal Affinity Chromatography |
eng |
dc.subject |
Mass Spectrometry |
eng |
dc.subject.ddc |
610 | Medizin, Gesundheit
|
ger |
dc.subject.ddc |
570 | Biowissenschaften, Biologie
|
ger |
dc.title |
Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography |
eng |
dc.type |
Article |
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dc.type |
Text |
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dc.relation.essn |
2040-2511 |
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dc.relation.issn |
2040-2503 |
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dc.relation.doi |
http://dx.doi.org/10.1039/C4MD00007B |
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dc.bibliographicCitation.issue |
4 |
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dc.bibliographicCitation.volume |
5 |
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dc.bibliographicCitation.firstPage |
540 |
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dc.bibliographicCitation.lastPage |
546 |
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dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
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