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Originalpublikation
Schlie, S.; Ngezahayo, A.; Ovsianikov, A.; Fabian, T.; Kolb, H.-A. et al.: Three-dimensional cell growth on structures fabricated from ORMOCER® by two-photon polymerization technique. In: Journal of Biomaterials Applications 22 (2007), Nr. 3, S. 275-287. DOI: https://doi.org/10.1177/0885328207077590
Version im Repositorium
Zum Zitieren der Version im Repositorium verwenden Sie bitte diesen DOI:
https://doi.org/10.15488/3056
| Zusammenfassung: | |
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Two-photon polymerization technique was applied to generate three-dimensional (3D) scaffold-like structures using the photosensitive organic-inorganic hybrid polymer ORMOCER®. The structures were studied with respect to potential applications as scaffold for tissue engineering. Cell counting and comet assay, respectively, demonstrated that doubling time and DNA strand breaks of CHO cells, GFSHR-17 granulosa cells, GM-7373 endothelial cells, and SH-SY5Y neuroblastoma cells were not affected by ORMOCER®. ORMOCER® related alteration of formation of tissue specific cell-to-cell adhesions like gap junctions was ruled out by double whole-cell patch-clamp technique. Additionally, growth of cells on the vertical surfaces of 3D structures composed of ORMOCER® is shown. © 2007 Sage Publications.
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| Lizenzbestimmungen: | Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
| Publikationstyp: | Article |
| Publikationsstatus: | publishedVersion |
| Erstveröffentlichung: | 2007 |
| Schlagwörter (englisch): | 3D scaffolds, Comet assay, DNA strand breaks, Gap junction, ORMOCER®, Tissue engineering, Two-photon polymerization, Bioassay, Cell adhesion, Computer simulation, DNA, Endothelial cells, Hybrid materials, Photosensitivity, Polymerization, Tissue engineering, Cell counting, Comet assay, Gap junction, Two-photon polymerization, Cell growth, biomaterial, Ormocer, polymer, silane derivative, unclassified drug, animal, article, cell adhesion, cell communication, cell junction, cell membrane potential, cell proliferation, ceramics, chemistry, CHO cell, computer aided design, Cricetulus, DNA damage, drug effect, genetics, hamster, human, instrumentation, laser, materials testing, methodology, photochemistry, physiology, radiation exposure, tissue engineering, tissue regeneration, tissue scaffold, tumor cell line, Animals, Biocompatible Materials, Cell Adhesion, Cell Communication, Cell Line, Tumor, Cell Proliferation, Ceramics, CHO Cells, Computer-Aided Design, Cricetinae, Cricetulus, DNA Damage, Gap Junctions, Guided Tissue Regeneration, Humans, Lasers, Materials Testing, Membrane Potentials, Photochemistry, Polymers, Silanes, Tissue Engineering, Tissue Scaffolds |
| Fachliche Zuordnung (DDC): | 610 | Medizin, Gesundheit |
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