dc.identifier.uri |
http://dx.doi.org/10.15488/16943 |
|
dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/17070 |
|
dc.contributor.author |
McGuire, Katie
|
|
dc.contributor.author |
He, Suhang
|
|
dc.contributor.author |
Gracie, Jennifer
|
|
dc.contributor.author |
Bryson, Charlotte
|
|
dc.contributor.author |
Zheng, Dazhong
|
|
dc.contributor.author |
Clark, Alasdair W.
|
|
dc.contributor.author |
Koehnke, Jesko
|
|
dc.contributor.author |
France, David J.
|
|
dc.contributor.author |
Nau, Werner M.
|
|
dc.contributor.author |
Lee, Tung-Chun
|
|
dc.contributor.author |
Peveler, William J.
|
|
dc.date.accessioned |
2024-04-09T05:46:54Z |
|
dc.date.available |
2024-04-09T05:46:54Z |
|
dc.date.issued |
2023 |
|
dc.identifier.citation |
McGuire, K.; He, S.; Gracie, J.; Bryson, C.; Zheng, D. et al.: Supramolecular Click Chemistry for Surface Modification of Quantum Dots Mediated by Cucurbit[7]uril. In: ACS Nano 17 (2023), Nr. 21, S. 21585-21594. DOI: https://doi.org/10.1021/acsnano.3c06601 |
|
dc.description.abstract |
Cucurbiturils (CBs), barrel-shaped macrocyclic molecules, are capable of self-assembling at the surface of nanomaterials in their native state, via their carbonyl-ringed portals. However, the symmetrical two-portal structure typically leads to aggregated nanomaterials. We demonstrate that fluorescent quantum dot (QD) aggregates linked with CBs can be broken-up, retaining CBs adsorbed at their surface, via inclusion of guests in the CB cavity. Simultaneously, the QD surface is modified by a functional tail on the guest, thus the high affinity host-guest binding (logKa > 9) enables a non-covalent, click-like modification of the nanoparticles in aqueous solution. We achieved excellent modification efficiency in several functional QD conjugates as protein labels. Inclusion of weaker-binding guests (logKa = 4-6) enables subsequent displacement with stronger binders, realising modular switchable surface chemistries. Our general “hook-and-eye” approach to host-guest chemistry at nanomaterial interfaces will lead to divergent routes for nano-architectures with rich functionalities for theranostics and photonics in aqueous systems. |
eng |
dc.language.iso |
eng |
|
dc.publisher |
Washington, DC : Soc. |
|
dc.relation.ispartofseries |
ACS Nano 17 (2023), Nr. 21 |
|
dc.rights |
CC BY 4.0 Unported |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0 |
|
dc.subject |
click-chemistry |
eng |
dc.subject |
cucurbiturils |
eng |
dc.subject |
host−guest complexes |
eng |
dc.subject |
nanoparticles |
eng |
dc.subject |
quantum dots |
eng |
dc.subject.ddc |
540 | Chemie
|
|
dc.title |
Supramolecular Click Chemistry for Surface Modification of Quantum Dots Mediated by Cucurbit[7]uril |
eng |
dc.type |
Article |
|
dc.type |
Text |
|
dc.relation.essn |
1936-086X |
|
dc.relation.issn |
1936-0851 |
|
dc.relation.doi |
https://doi.org/10.1021/acsnano.3c06601 |
|
dc.bibliographicCitation.issue |
21 |
|
dc.bibliographicCitation.volume |
17 |
|
dc.bibliographicCitation.firstPage |
21585 |
|
dc.bibliographicCitation.lastPage |
21594 |
|
dc.description.version |
publishedVersion |
|
tib.accessRights |
frei zug�nglich |
|