dc.identifier.uri |
http://dx.doi.org/10.15488/16707 |
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dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/16834 |
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dc.contributor.author |
Haufe, Sven
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dc.contributor.author |
Hupa-Breier, Katharina L.
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dc.contributor.author |
Bayerle, Pauline
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dc.contributor.author |
Boeck, Hedwig T.
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dc.contributor.author |
Rolff, Simone
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dc.contributor.author |
Sundermeier, Thorben
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dc.contributor.author |
Kerling, Arno
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dc.contributor.author |
Eigendorf, Julian
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dc.contributor.author |
Kück, Momme
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dc.contributor.author |
Hanke, Alexander A.
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dc.contributor.author |
Ensslen, Ralf
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dc.contributor.author |
Nachbar, Lars
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dc.contributor.author |
Lauenstein, Dirk
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dc.contributor.author |
Böthig, Dietmar
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dc.contributor.author |
Hilfiker-Kleiner, Denise
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dc.contributor.author |
Stiesch, Meike
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dc.contributor.author |
Terkamp, Christoph
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dc.contributor.author |
Wedemeyer, Heiner
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dc.contributor.author |
Haverich, Axel
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dc.contributor.author |
Tegtbur, Uwe
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dc.date.accessioned |
2024-03-21T10:09:23Z |
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dc.date.available |
2024-03-21T10:09:23Z |
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dc.date.issued |
2021 |
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dc.identifier.citation |
Haufe, S.; Hupa-Breier, K.L.; Bayerle, P.; Boeck, H.T.; Rolff, S. et al.: Telemonitoring-Supported Exercise Training in Employees With Metabolic Syndrome Improves Liver Inflammation and Fibrosis. In: Clinical and Translational Gastroenterology 12 (2021), Nr. 6, e00371. DOI: https://doi.org/10.14309/ctg.0000000000000371 |
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dc.description.abstract |
INTRODUCTION:Metabolic syndrome (MetS) is a major health problem worldwide and the main risk factor for metabolic-associated fatty liver disease (MAFLD). Established treatment options are lifestyle interventions facilitating dietary change and increased physical activity. Here, we tested the effect of a telemonitoring-supported intervention on liver parameter of inflammation and fibrosis in individuals with MetS.METHODS:This was a prospective, randomized, parallel-group, and assessor-blind study performed in workers of the main Volkswagen factory (Wolfsburg, Germany). Volunteers with diagnosed MetS were randomly assigned (1:1) to a 6-month lifestyle intervention focusing on supervised, activity-tracker-guided exercise or to a waiting-list control group. This secondary analysis assessed the effect of the intervention on liver enzymes and MAFLD-related parameters.RESULTS:We screened 543 individuals between October 10, 2017, and February 27, 2018, of whom 314 were randomly assigned to the intervention group (n = 160) or control group (n = 154). Liver transaminases, alkaline phosphatase, and gamma-glutamyl transferase significantly decreased after 6 months in the intervention group compared with the CG. Furthermore, an aspartate aminotransferase-to-platelet ratio index score as a marker for liver fibrosis significantly decreased in the intervention group. These improvements were associated with changes in obesity and exercise capacity.DISCUSSION:A 6-month lifestyle intervention based on exercise training with individualized telemonitoring-based supervision led to improvements of liver inflammation and fibrosis in employees with MetS. Therefore, this intervention shows therapeutic potential for individuals at high risk of MAFLD (ClinicalTrials.gov Identifier: NCT03293264). |
eng |
dc.language.iso |
eng |
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dc.publisher |
London : Nature Publ. Group |
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dc.relation.ispartofseries |
Clinical and Translational Gastroenterology 12 (2021), Nr. 6 |
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dc.rights |
CC BY-NC-ND 4.0 Unported |
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dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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dc.subject |
Adult |
eng |
dc.subject |
Exercise |
eng |
dc.subject |
Exercise Therapy |
eng |
dc.subject |
Female |
eng |
dc.subject |
Germany |
eng |
dc.subject |
Humans |
eng |
dc.subject |
Life Style |
eng |
dc.subject |
Linear Models |
eng |
dc.subject |
Liver |
eng |
dc.subject |
Liver Cirrhosis |
eng |
dc.subject |
Liver Function Tests |
eng |
dc.subject |
Male |
eng |
dc.subject |
Metabolic Syndrome |
eng |
dc.subject |
Middle Aged |
eng |
dc.subject |
Obesity |
eng |
dc.subject |
Prospective Studies |
eng |
dc.subject |
Telemetry |
eng |
dc.subject |
Wearable Electronic Devices |
eng |
dc.subject |
alanine aminotransferase |
eng |
dc.subject |
alkaline phosphatase |
eng |
dc.subject |
aminotransferase |
eng |
dc.subject |
anticoagulant agent |
eng |
dc.subject |
antidiabetic agent |
eng |
dc.subject |
antihypertensive agent |
eng |
dc.subject |
antilipemic agent |
eng |
dc.subject |
aspartate aminotransferase |
eng |
dc.subject |
creatinine |
eng |
dc.subject |
gamma glutamyltransferase |
eng |
dc.subject |
hemoglobin A1c |
eng |
dc.subject |
low density lipoprotein cholesterol |
eng |
dc.subject |
urea |
eng |
dc.subject |
adult |
eng |
dc.subject |
alcohol consumption |
eng |
dc.subject |
anxiety |
eng |
dc.subject |
aspartate aminotransferase to platelet ratio index |
eng |
dc.subject |
body composition |
eng |
dc.subject |
carbohydrate intake |
eng |
dc.subject |
cholesterol blood level |
eng |
dc.subject |
cohort analysis |
eng |
dc.subject |
controlled study |
eng |
dc.subject |
depression |
eng |
dc.subject |
exercise |
eng |
dc.subject |
female |
eng |
dc.subject |
Freiburger Physical Activity Questionnaire |
eng |
dc.subject |
general health status assessment |
eng |
dc.subject |
hepatitis |
eng |
dc.subject |
human |
eng |
dc.subject |
hypertransaminasemia |
eng |
dc.subject |
liver fibrosis |
eng |
dc.subject |
liver injury |
eng |
dc.subject |
major clinical study |
eng |
dc.subject |
male |
eng |
dc.subject |
metabolic fatty liver |
eng |
dc.subject |
metabolic syndrome X |
eng |
dc.subject |
middle aged |
eng |
dc.subject |
obesity |
eng |
dc.subject |
platelet count |
eng |
dc.subject |
prospective study |
eng |
dc.subject |
protein intake |
eng |
dc.subject |
randomized controlled trial (topic) |
eng |
dc.subject |
Short Form 36 |
eng |
dc.subject |
telemonitoring |
eng |
dc.subject |
electronic device |
eng |
dc.subject |
exercise |
eng |
dc.subject |
Germany |
eng |
dc.subject |
kinesiotherapy |
eng |
dc.subject |
lifestyle |
eng |
dc.subject |
liver |
eng |
dc.subject |
liver cirrhosis |
eng |
dc.subject |
liver function test |
eng |
dc.subject |
metabolic syndrome X |
eng |
dc.subject |
obesity |
eng |
dc.subject |
pathology |
eng |
dc.subject |
pathophysiology |
eng |
dc.subject |
procedures |
eng |
dc.subject |
randomized controlled trial |
eng |
dc.subject |
statistical model |
eng |
dc.subject |
telemetry |
eng |
dc.subject.ddc |
610 | Medizin, Gesundheit
|
|
dc.title |
Telemonitoring-Supported Exercise Training in Employees With Metabolic Syndrome Improves Liver Inflammation and Fibrosis |
eng |
dc.type |
Article |
|
dc.type |
Text |
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dc.relation.essn |
2155-384X |
|
dc.relation.doi |
https://doi.org/10.14309/ctg.0000000000000371 |
|
dc.bibliographicCitation.issue |
6 |
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dc.bibliographicCitation.volume |
12 |
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dc.bibliographicCitation.firstPage |
e00371 |
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dc.description.version |
publishedVersion |
eng |
tib.accessRights |
frei zug�nglich |
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dc.bibliographicCitation.articleNumber |
e00371 |
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