Zusammenfassung: | |
INTRODUCTION:Metabolic syndrome (MetS) is a major health problem worldwide and the main risk factor for metabolic-associated fatty liver disease (MAFLD). Established treatment options are lifestyle interventions facilitating dietary change and increased physical activity. Here, we tested the effect of a telemonitoring-supported intervention on liver parameter of inflammation and fibrosis in individuals with MetS.METHODS:This was a prospective, randomized, parallel-group, and assessor-blind study performed in workers of the main Volkswagen factory (Wolfsburg, Germany). Volunteers with diagnosed MetS were randomly assigned (1:1) to a 6-month lifestyle intervention focusing on supervised, activity-tracker-guided exercise or to a waiting-list control group. This secondary analysis assessed the effect of the intervention on liver enzymes and MAFLD-related parameters.RESULTS:We screened 543 individuals between October 10, 2017, and February 27, 2018, of whom 314 were randomly assigned to the intervention group (n = 160) or control group (n = 154). Liver transaminases, alkaline phosphatase, and gamma-glutamyl transferase significantly decreased after 6 months in the intervention group compared with the CG. Furthermore, an aspartate aminotransferase-to-platelet ratio index score as a marker for liver fibrosis significantly decreased in the intervention group. These improvements were associated with changes in obesity and exercise capacity.DISCUSSION:A 6-month lifestyle intervention based on exercise training with individualized telemonitoring-based supervision led to improvements of liver inflammation and fibrosis in employees with MetS. Therefore, this intervention shows therapeutic potential for individuals at high risk of MAFLD (ClinicalTrials.gov Identifier: NCT03293264).
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Lizenzbestimmungen: | CC BY-NC-ND 4.0 Unported - https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Publikationstyp: | Article |
Publikationsstatus: | publishedVersion |
Erstveröffentlichung: | 2021 |
Schlagwörter (englisch): | Adult, Exercise, Exercise Therapy, Female, Germany, Humans, Life Style, Linear Models, Liver, Liver Cirrhosis, Liver Function Tests, Male, Metabolic Syndrome, Middle Aged, Obesity, Prospective Studies, Telemetry, Wearable Electronic Devices, alanine aminotransferase, alkaline phosphatase, aminotransferase, anticoagulant agent, antidiabetic agent, antihypertensive agent, antilipemic agent, aspartate aminotransferase, creatinine, gamma glutamyltransferase, hemoglobin A1c, low density lipoprotein cholesterol, urea, adult, alcohol consumption, anxiety, aspartate aminotransferase to platelet ratio index, body composition, carbohydrate intake, cholesterol blood level, cohort analysis, controlled study, depression, exercise, female, Freiburger Physical Activity Questionnaire, general health status assessment, hepatitis, human, hypertransaminasemia, liver fibrosis, liver injury, major clinical study, male, metabolic fatty liver, metabolic syndrome X, middle aged, obesity, platelet count, prospective study, protein intake, randomized controlled trial (topic), Short Form 36, telemonitoring, electronic device, exercise, Germany, kinesiotherapy, lifestyle, liver, liver cirrhosis, liver function test, metabolic syndrome X, obesity, pathology, pathophysiology, procedures, randomized controlled trial, statistical model, telemetry |
Fachliche Zuordnung (DDC): | 610 | Medizin, Gesundheit |
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