dc.identifier.uri |
http://dx.doi.org/10.15488/12744 |
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dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/12844 |
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dc.contributor.author |
Tasneem, Rabia
|
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dc.contributor.author |
Khan, Haji Muhammad Shoaib
|
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dc.contributor.author |
Rasool, Fatima
|
|
dc.contributor.author |
Khan, Kashif-ur-Rehman
|
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dc.contributor.author |
Umair, Muhammad
|
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dc.contributor.author |
Esatbeyoglu, Tuba
|
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dc.contributor.author |
Korma, Sameh A.
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dc.date.accessioned |
2022-09-08T12:03:16Z |
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dc.date.available |
2022-09-08T12:03:16Z |
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dc.date.issued |
2022 |
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dc.identifier.citation |
Tasneem, R.; Khan, H.M.S.; Rasool, F.; Khan, K.-u.-R.; Umair, M. et al.: Development of Phytocosmeceutical Microemulgel Containing Flaxseed Extract and Its In Vitro and In Vivo Characterization. In: Pharmaceutics 14 (2022), Nr. 8, 1656. DOI: https://doi.org/10.3390/pharmaceutics14081656 |
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dc.description.abstract |
Antioxidants from natural sources are extensively attaining consideration to avert the skin from damage and aging caused by free radicals. Flaxseed (Linum usitatissimum L.), a natural therapeutic agent, was meant to be explored cosmeceutical by quantifying its potential phytoconstituents and to be incorporated into a microemulgel for topical use. Hydroalcoholic fractions (both methanolic and ethanolic; 80%) flaxseed extracts were subjected to phytochemical screening by quantifying total phenolic content (TPC), total flavonoid content (TFC), and high-performance liquid chromatography-ultraviolet (HPLC-UV), and for biological activities through 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, tyrosinase inhibition assay, and sun protection factor (SPF). Ethanolic fraction was selected for further study by TPC (18.75 mg gallic acid equivalent/g) and TFC (1.34 mg quercetin equivalent/g). HPLC-UV analysis showed the existence of benzoic, quercetin, caffeic, vanillic, p-coumaric, gallic, cinnamic, syringic, and sinapic acids. Biological activities showed 87.00%, 72.00%, and 21.75 values for DPPH assay, tyrosinase inhibition, and SPF assays, respectively. An oil-in-water (OW) microemulsion containing the flaxseed extract, with 99.20 nm Zeta size, −19.3 Zeta potential and 0.434 polydispersity index was developed and incorporated in Carbopol-940 gel matrix to formulate an active microemulgel with 59.15% release in in vitro studies. The successfully formulated stable active microemulgel produced statistically significant effects (p < 0.05), in comparison to a placebo, on skin erythema, melanin, sebum, moisture, and elasticity, in a noninvasive in vivo study performed on 13 healthy human female volunteers. Other cosmeceutical products can also be formulated from flaxseed, making it a considerable candidate for further utilization in the pharmaceutical industry. |
eng |
dc.language.iso |
eng |
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dc.publisher |
Basel : MDPI |
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dc.relation.ispartofseries |
Pharmaceutics 14 (2022), Nr. 8 |
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dc.rights |
CC BY 4.0 Unported |
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dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
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dc.subject |
antioxidant |
eng |
dc.subject |
cosmetic |
eng |
dc.subject |
formulation development |
eng |
dc.subject |
HPLC-UV |
eng |
dc.subject |
in vivo study |
eng |
dc.subject |
Linum usitatissimum |
eng |
dc.subject |
pharmaceutic |
eng |
dc.subject |
topical |
eng |
dc.subject |
phytocosmetics |
eng |
dc.subject |
radical scavenging activity |
eng |
dc.subject.ddc |
610 | Medizin, Gesundheit
|
ger |
dc.title |
Development of Phytocosmeceutical Microemulgel Containing Flaxseed Extract and Its In Vitro and In Vivo Characterization |
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dc.type |
Article |
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dc.type |
Text |
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dc.relation.essn |
1999-4923 |
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dc.relation.doi |
https://doi.org/10.3390/pharmaceutics14081656 |
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dc.bibliographicCitation.issue |
8 |
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dc.bibliographicCitation.volume |
14 |
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dc.bibliographicCitation.firstPage |
1656 |
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dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
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