Ulusoy, Mehriban; Walter, Johanna-Gabriela; Lavrentieva, Antonina; Kretschmer, Imme; Sandiford, Lydia; Le Marois, Alix; Scheper, Thomas et al.: One-pot aqueous synthesis of highly strained CdTe/CdS/ZnS nanocrystals and their interactions with cells. In: RSC Advances 5 (10), S. 7485-7494. DOI:
http://dx.doi.org/10.1039/c4ra13386b
Abstract: |
In this work, a very simple one-pot synthetic approach was developed to generate aqueous CdTe/CdS/ZnS type-II/type-I red-emitting nanocrystals (NCs). Strain-induced optical properties of CdTe/CdS particles having core((small))/shell((thick)) structure with a maximum quantum yield (QY(max)) similar to 57% were further improved with the overgrowth of a ZnS shell, resulting in a core((small))/shell((thick))/shell((small)) structure (QY(max) similar to 64%). The spectral properties were tuned further to the near-infrared region as the ZnS shell grew in thickness. X-ray powder diffraction (XRD) analysis and high-resolution transmission electron microscope (HRTEM) images showed the crystalline structure of NCs proving the epitaxial growth of ZnS without crystalline defects. Under continuous UV-irradiation for 5 h, the NCs did not exhibit any photo-degradation but instead displayed a photo-annealing process. These extremely photostable NCs were further characterized in terms of their cytotoxicity and their cell labeling performances. The presence of a ZnS shell was found to reduce the toxicity of the CdTe/CdS NCs. Furthermore, aptamer-conjugated NCs were successfully utilized in targeted cell imaging. Promisingly, the aptamer-NCs bioconjugates were internalized by A549 cells within 2 hours of incubation and retained their fluorescence even after 24 hours of internalization.
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License of this version: |
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Publication type: |
Article |
Publishing status: |
publishedVersion |
Publication date: |
2014-12-22 |
Keywords english: |
Shell Quantum Dots, Semiconductor Nanocrystals, Energy-Transfer, Aptamers, Nanoparticles, Phase, Fluorescence, Growth
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DDC: |
540 | Chemie
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