dc.identifier.uri |
http://dx.doi.org/10.15488/10987 |
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dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/11069 |
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dc.contributor.author |
Allers, Maria
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dc.contributor.author |
Langejuergen, Jens
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dc.contributor.author |
Gaida, Arne
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dc.contributor.author |
Holz, O.
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dc.contributor.author |
Schuchardt, Sven
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dc.contributor.author |
Hohlfeld, Jens M.
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dc.contributor.author |
Zimmermann, Stefan
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dc.date.accessioned |
2021-05-25T05:04:16Z |
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dc.date.available |
2021-05-25T05:04:16Z |
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dc.date.issued |
2016 |
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dc.identifier.citation |
Allers, M.; Langejuergen, J.; Gaida, A.; Holz, O.; Schuchardt, S. et al.: Measurement of exhaled volatile organic compounds from patients with chronic obstructive pulmonary disease (COPD) using closed gas loop GC-IMS and GC-APCI-MS. In: Journal of breath research : volatiles for medical diagnosis 10 (2016), Nr. 2, 026004. DOI: https://doi.org/10.1088/1752-7155/10/2/026004 |
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dc.description.abstract |
Due to its high sensitivity, compact size and low cost Ion Mobility Spectrometry (IMS) has the potential to become a point-of-care breath analyzer. Therefore, we developed a prototype of a compact, closed gas loop IMS with gas chromatographic (GC) pre-separation and high resolving power of R = 90. In this study, we evaluated the performance of this GC-IMS under clinical conditions in a COPD study to find correlations between VOCs (10 ppbv to 1 ppmv) and COPD. Furthermore, in order to investigate possible correlations between ultra-low concentrated breath VOCs (0.1 pptv to 1 ppbv) and COPD, a modified mass spectrometer (MS) with atmospheric pressure chemical ionization (APCI) and GC pre-separation (GC-APCI-MS) was used. The GC-IMS has been used in 58 subjects (21 smokers with moderate COPD, 12 ex-smokers with COPD, 16 healthy smokers and 9 non-smokers). GC-APCI-MS data were available for 94 subjects (21 smokers with moderate COPD, 25 ex-smokers with COPD, 25 healthy smokers and 23 non-smokers). For 44 subjects, a comparison between GC-IMS and GC-APCI-MS data could be performed. Due to service intervals, subject availability and corrupt data, patient numbers were different for GC-APCI-MS and GC-IMS measurements. Using GC-IMS, three VOCs have been found showing a significant difference between healthy controls and patients with COPD. In the GC-APCI-MS data, we only observed one distinctive VOC, which has been identified as 2-pentanone. This proof-of-principle study shows the potential of our high-resolution GC-IMS in the clinical environment. Due to different linear dynamic response ranges, the data of GC-IMS and GC-APCI-MS were only comparable to a limited extent. |
eng |
dc.language.iso |
eng |
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dc.publisher |
Bristol : IOP |
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dc.relation.ispartofseries |
Journal of breath research : volatiles for medical diagnosis 10 (2016), Nr. 2 |
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dc.rights |
Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. |
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dc.subject |
COPD |
eng |
dc.subject |
GC-IMS |
eng |
dc.subject |
GC-APCI-MS |
eng |
dc.subject |
VOC |
eng |
dc.subject |
biomarker |
eng |
dc.subject |
breath analysis |
eng |
dc.subject.ddc |
610 | Medizin, Gesundheit
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ger |
dc.title |
Measurement of exhaled volatile organic compounds from patients with chronic obstructive pulmonary disease (COPD) using closed gas loop GC-IMS and GC-APCI-MS |
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dc.type |
Article |
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dc.type |
Text |
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dc.relation.essn |
1752-7163 |
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dc.relation.issn |
1752-7155 |
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dc.relation.doi |
https://doi.org/10.1088/1752-7155/10/2/026004 |
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dc.bibliographicCitation.issue |
2 |
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dc.bibliographicCitation.volume |
10 |
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dc.bibliographicCitation.firstPage |
26004 |
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dc.description.version |
acceptedVersion |
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tib.accessRights |
frei zug�nglich |
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