Recent experiments show that periodic modulations of cold atoms in optical lattices may be used to engineer and explore interesting models. We show that double modulation combining lattice shaking and modulated interactions allows for the engineering of a much broader class of lattice with correlated hopping, which we study for the particular case of one-dimensional systems. We show, in particular, that by using this double modulation it is possible to study Hubbard models with asymmetric hopping, which, contrary to the standard Hubbard model, present insulating phases with both parity and string order. Moreover, double modulation allows for the simulation of lattice models in unconventional parameter regimes, as we illustrate for the case of the spin-1/2 Fermi-Hubbard model with correlated hopping, a relevant model for cuprate superconductors. © 2014 American Physical Society.