Youth empowerment has become a growing concern for achieving sustainable development worldwide. Yet, there is limited evidence on which domains of empowerment are important for youth and how they can be operationalized with indicators for measurement. We propose four domains of youth empowerment with corresponding indicators and use a well-established methodology for constructing a composite index. Using data from a household survey in Tunisia, we assess youth empowerment in the proposed domains and explore their relation to youth well-being. The proposed approach can help monitor youth empowerment in various contexts and evaluate the effectiveness of youth interventions.