In the current study, the wear behavior of bronze-bonded grinding tools when grinding the titanium alloy Ti-6Al-4V was explored. In this process, oxidation plays a key role since both the bronze bond and the titanium workpiece chemically react with oxygen. The oxidation effect is intensified further due to increased temperatures during grinding and can cause tribo-oxidation. This wear effect can be reduced or even eliminated by grinding in an extreme high-vacuum (XHV) adequate atmosphere. This atmosphere is nearly oxygen-free and is generated using a silane-doped argon gas that chemically reacts with oxygen. This reaction is able to decrease the oxygen partial pressure (pO2 ≤ 10−12 mbar) down to an XHV-adequate atmosphere. The aim of this paper is to investigate the influence of oxygen in the atmosphere on the application and wear behavior during grinding and to demonstrate the potential of this novel approach. The results presented show that during grinding with cBN, the process forces are significantly influenced by the atmosphere. Depending on the process parameters, a reduction of up to 93% is thus possible. This force reduction correlates with radial tool wear. When grinding under oxygen-free conditions, it can be reduced by up to 64%.