Cassava is a staple food and a major source of income for many smallholder farmers. However, its yields are less than 6 t ha-1 compared to a potential yield of 20-25 t ha-1 in Zambia. Understanding cropping practices and constraints in cassava production systems is imperative for sustainable intensification. Therefore, a survey of 40 households each with three fields of cassava at 12, 24, and 36 months after planting (MAP) was conducted. Analyzed soil data, leaf area index (LAI), intercepted photosynthetically active radiation, and management practices from 120 fields were collected and subjected to descriptive statistics. To explain yield differences within the same cassava growth stage group, the data were grouped into low- and high-yield categories using the median, before applying a nonparametric test for one independent sample. Stepwise regressions were performed on each growth stage and the whole dataset to determine factors affecting tuber yield. Cassava intercropping and monocropping systems were the main cropping systems for the 12 and 24-36 MAP, respectively. Cassava yields declined by 209 and 633 kg ha-1 at 12 and 36 MAP due to soil nutrient depletion for each year of cultivation until field abandonment at 8-9 years. Fresh cassava yields ranged from 3.51-8.51, 13.52-25.84, and 16.92-30.98 t ha-1 at 12, 24, and 36 MAP, respectively. For every one unit increment in exchangeable K (cmol (+)/kg soil), cassava yield increased by 435, 268, and 406 kg ha-1 at 12, 24, and 36 MAP, respectively. One unit increment of magnesium (cmol (+)/kg soil) gave the highest yield increase of 525 kg ha-1 at 24 MAP. The low levels of soil organic carbon explained the deficient nitrogen in cassava fields, which limits the LAI growth and consequently reduced intercepted radiation and low yields. The effect of exchangeable K on growth was limited by the moderate availability of Mg and low N, thus the need for balanced fertilizer regimes. © 2021 Peter Kaluba et al.