Calibrating mini-mental state examination scores to predict misdiagnosed dementia patients

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Vyas, A.; Aisopos, F.; Vidal, M.-E.; Garrard, P.; Paliouras, G.: Calibrating mini-mental state examination scores to predict misdiagnosed dementia patients. In: Applied Sciences (Switzerland) 11 (2021), Nr. 17, 8055. DOI: https://doi.org/10.3390/app11178055

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To cite the version in the repository, please use this identifier: https://doi.org/10.15488/12437

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Sum total of downloads: 63




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Abstract: 
Mini-Mental State Examination (MMSE) is used as a diagnostic test for dementia to screen a patient’s cognitive assessment and disease severity. However, these examinations are often inaccurate and unreliable either due to human error or due to patients’ physical disability to correctly interpret the questions as well as motor deficit. Erroneous data may lead to a wrong assessment of a specific patient. Therefore, other clinical factors (e.g., gender and comorbidities) existing in electronic health records, can also play a significant role, while reporting her examination results. This work considers various clinical attributes of dementia patients to accurately determine their cognitive status in terms of the Mini-Mental State Examination (MMSE) Score. We employ machine learning models to calibrate MMSE score and classify the correctness of diagnosis among patients, in order to assist clinicians in a better understanding of the progression of cognitive impairment and subsequent treatment. For this purpose, we utilize a curated real-world ageing study data. A random forest prediction model is employed to estimate the Mini-Mental State Examination score, related to the diagnostic classification of patients.This model uses various clinical attributes to provide accurate MMSE predictions, succeeding in correcting an important percentage of cases that contain previously identified miscalculated scores in our dataset. Furthermore, we provide an effective classification mechanism for automatically identifying patient episodes with inaccurate MMSE values with high confidence. These tools can be combined to assist clinicians in automatically finding episodes within patient medical records where the MMSE score is probably miscalculated and estimating what the correct value should be. This provides valuable support in the decision making process for diagnosing potential dementia patients. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
License of this version: CC BY 4.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2021
Appears in Collections:Forschungszentren

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pos. country downloads
total perc.
1 image of flag of United States United States 28 44.44%
2 image of flag of Germany Germany 19 30.16%
3 image of flag of China China 5 7.94%
4 image of flag of Netherlands Netherlands 2 3.17%
5 image of flag of France France 2 3.17%
6 image of flag of Vietnam Vietnam 1 1.59%
7 image of flag of Ukraine Ukraine 1 1.59%
8 image of flag of Taiwan Taiwan 1 1.59%
9 image of flag of Italy Italy 1 1.59%
10 image of flag of Israel Israel 1 1.59%
    other countries 2 3.17%

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