Auflistung nach Schlagwort "thermophoresis"

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  • A Chemical Chaperone Restores Connexin 26 Mutant Activity 
    Wang, Dahua; Wang, Hongling; Fan, Lu; Ludwig, Tobias; Wegner, Andre; Stahl, Frank; Harre, Jennifer; Warnecke, Athanasia; Zeilinger, Carsten (Washington, DC : ACS Publications, 2023)
    Mutations in connexin 26 (Cx26) cause hearing disorders of a varying degree. Herein, to identify compounds capable of restoring the function of mutated Cx26, a novel miniaturized microarray-based screening system was ...
  • Development of Aptamer-Based TID Assays Using Thermophoresis and Microarrays 
    Kurth, Tracy; Witt, Sandra; Bolten, Svenja; Waniek, Janice-Joy; Kortmann, Carlotta; Lavrentieva, Antonina; Scheper, Thomas; Walter, Johanna-Gabriela (Basel : MDPI AG, 2019)
    Aptamers are single-stranded oligonucleotides which can be used as alternative recognition elements for protein detection, because aptamers bind their targets with a high affinity similar to antibodies. Due to the ...
  • Triiodothyronine Acts as a Smart Influencer on Hsp90 via a Triiodothyronine Binding Site 
    Fan, Lu; Warnecke, Athanasia; Weder, Julia; Preller, Matthias; Zeilinger, Carsten (Basel : Molecular Diversity Preservation International (MDPI), 2022)
    Microarray-based experiments revealed that thyroid hormone triiodothyronine (T3) enhanced the binding of Cy5-labeled ATP on heat shock protein 90 (Hsp90). By molecular docking experiments with T3 on Hsp90, we identified a ...