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Browsing by Subject "Drug Design"

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Computer-Aided Design and Synthesis of a New Class of PEX14 Inhibitors: Substituted 2,3,4,5-Tetrahydrobenzo[F][1,4]oxazepines as Potential New Trypanocidal Agents

Fino, Roberto; Lenhart, Dominik; Kalel, Vishal C.; Softley, Charlotte A.; Napolitano, Valeria; Byrne, Ryan; Schliebs, Wolfgang; Dawidowski, Maciej; Erdmann, Ralf; Sattler, Michael; Schneider, Gisbert; Plettenburg, Oliver; Popowicz, Grzegorz M. (Washington, DC : American Chemical Society, 2021)

African and American trypanosomiases are estimated to affect several million people across the world, with effective treatments distinctly lacking. New, ideally oral, treatments with higher efficacy against these diseases ...
Structure-Activity Relationship in Pyrazolo[4,3- c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity

Dawidowski, Maciej; Kalel, Vishal C.; Napolitano, Valeria; Fino, Roberto; Schorpp, Kenji; Emmanouilidis, Leonidas; Lenhart, Dominik; Ostertag, Michael; Kaiser, Marcel; Kolonko, Marta; Tippler, Bettina; Schliebs, Wolfgang; Dubin, Grzegorz; Mäser, Pascal; Tetko, Igor V.; Hadian, Kamyar; Plettenburg, Oliver; Erdmann, Ralf; Sattler, Michael; Popowicz, Grzegorz M. (Washington, DC : ACS, 2019)

Trypanosoma protists are pathogens leading to a spectrum of devastating infectious diseases. The range of available chemotherapeutics against Trypanosoma is limited, and the existing therapies are partially ineffective and ...
Targeting heat-shock-protein 90 (Hsp90) by natural products: Geldanamycin, a show case in cancer therapy

Franke, Jana; Eichner, Simone; Zeilinger, Carsten; Kirschning, Andreas (Cambridge : Royal Society of Chemistry, 2013)

Covering: 2005 to 2013 In this review recent progress in the development of heat shock proteins (Hsp90) in oncogenesis is illuminated. Particular emphasis is put on inhibitors such as geldanamycin and analogues that serve ...

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Browsing by Subject "Drug Design"

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