Browsing by Subject "CHO cell line"

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Application of an online-biomass sensor in an optical multisensory platform prototype for growth monitoring of biotechnical relevant microorganism and cell lines in single-use shake flasks

Ude, Christian; Schmidt-Hager, Jörg; Findeis, Michael; John, Gernot Thomas; Scheper, Thomas; Beutel, Sascha (Basel : MDPI AG, 2014)

In the context of this work we evaluated a multisensory, noninvasive prototype platform for shake flask cultivations by monitoring three basic parameters (pH, pO2 and biomass). The focus lies on the evaluation of the biomass ...
Continuous optical in-line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality

Lederle, Mario; Tric, Mircea; Roth, Tatjana; Schütte, Lina; Rattenholl, Anke; Lütkemeyer, Dirk; Wölfl, Stefan; Werner, Tobias; Wiedemann, Philipp (Weinheim : Wiley-VCH, 2021)

Great efforts are directed towards improving productivity, consistency and quality of biopharmaceutical processes and products. One particular area is the development of new sensors for continuous monitoring of critical ...

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