dc.identifier.uri |
http://dx.doi.org/10.15488/681 |
|
dc.identifier.uri |
http://www.repo.uni-hannover.de/handle/123456789/705 |
|
dc.contributor.author |
Knobloch, Tobias
|
|
dc.contributor.author |
Draeger, Gerald
|
|
dc.contributor.author |
Collisi, Wera
|
|
dc.contributor.author |
Sasse, Florenz
|
|
dc.contributor.author |
Kirschning, Andreas
|
|
dc.date.accessioned |
2016-11-09T10:37:57Z |
|
dc.date.available |
2016-11-09T10:37:57Z |
|
dc.date.issued |
2012 |
|
dc.identifier.citation |
Knobloch, Tobias; Dräger, Gerald; Collisi, W.; Sasse, F.; Kirschning, Andreas: Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations. In: Beilstein Journal of Organic Chemistry 8 (2012), S. 861-869. DOI: http://dx.doi.org/10.3762/bjoc.8.96 |
|
dc.description.abstract |
We describe the unprecedented formation of six ansamitocin derivatives that are deoxygenated at C-7 of the ansamitocin core, obtained during fermentation experiments by employing a variety of Actinosynnema pretiosum mutants and mutasynthetic approaches. We suggest that the formation of these derivatives is based on elimination at C-7/C-8 followed by reduction(s) of the intermediate enone. In bioactivity tests, only ansamitocin derivatives bearing an ester side chain at C-3 showed strong antiproliferative activity. |
eng |
dc.description.sponsorship |
DFG/ Ki-397/13-1 |
|
dc.description.sponsorship |
Fonds der Chemischen Industrie |
|
dc.language.iso |
eng |
|
dc.publisher |
Frankfurt am Main : Beilstein-Institut Zur Förderung der Chemischen Wissenschaften |
|
dc.relation.ispartofseries |
Beilstein Journal of Organic Chemistry 8 (2012) |
|
dc.rights |
CC BY 2.0 Unported |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/2.0/ |
|
dc.subject |
Ansamitocins |
eng |
dc.subject |
Antibiotics |
eng |
dc.subject |
Antitumor agents |
eng |
dc.subject |
Mutasynthesis |
eng |
dc.subject |
Natural products |
eng |
dc.subject.ddc |
500 | Naturwissenschaften
|
ger |
dc.subject.ddc |
540 | Chemie
|
ger |
dc.title |
Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations |
eng |
dc.type |
Article |
|
dc.type |
Text |
|
dc.relation.issn |
1860-5397 |
|
dc.relation.doi |
http://dx.doi.org/10.3762/bjoc.8.96 |
|
dc.bibliographicCitation.volume |
8 |
|
dc.bibliographicCitation.firstPage |
861 |
|
dc.bibliographicCitation.lastPage |
869 |
|
dc.description.version |
publishedVersion |
|
tib.accessRights |
frei zug�nglich |
|