Preparation of new alkyne-modified ansamitocins by mutasynthesis

Zur Kurzanzeige

dc.identifier.uri http://dx.doi.org/10.15488/645
dc.identifier.uri http://www.repo.uni-hannover.de/handle/123456789/669
dc.contributor.author Harmrolfs, Kirsten
dc.contributor.author Mancuso, Lena
dc.contributor.author Drung, Binia
dc.contributor.author Sasse, Florenz
dc.contributor.author Kirschning, Andreas
dc.date.accessioned 2016-11-03T12:40:16Z
dc.date.available 2016-11-03T12:40:16Z
dc.date.issued 2014
dc.identifier.citation Harmrolfs, Kirsten; Mancuso, Lena; Drung, Binia; Sasse, F.; Kirschning, Andreas: Preparation of new alkyne-modified ansamitocins by mutasynthesis. In: Beilstein Journal of Organic Chemistry 10 (2014), S. 535-543. DOI: http://dx.doi.org/10.3762/bjoc.10.49
dc.description.abstract The preparation of alkyne-modified ansamitocins by mutasynthetic supplementation of Actinosynnema pretiosum mutants with alkyne-substituted aminobenzoic acids is described. This modification paved the way to introduce a thiol linker by Huisgen-type cycloaddition which can principally be utilized to create tumor targeting conjugates. In bioactivity tests, only those new ansamitocin derivatives showed strong antiproliferative activity that bear an ester side chain at C-3. eng
dc.description.sponsorship DFG/Ki-397/13-1
dc.description.sponsorship Fonds der Chemischen Industrie
dc.language.iso eng
dc.publisher Frankfurt am Main : Beilstein-Institut zur Förderung der Chemischen Wissenschaften
dc.relation.ispartofseries Beilstein Journal of Organic Chemistry 10 (2014)
dc.rights CC BY 2.0 Unported
dc.rights.uri https://creativecommons.org/licenses/by/2.0/
dc.subject Ansamitocins eng
dc.subject Antibiotics eng
dc.subject Antitumor agents eng
dc.subject Click chemistry eng
dc.subject Mutasynthesis eng
dc.subject Natural products eng
dc.subject.ddc 500 | Naturwissenschaften ger
dc.subject.ddc 540 | Chemie ger
dc.title Preparation of new alkyne-modified ansamitocins by mutasynthesis
dc.type Article
dc.type Text
dc.relation.issn 1860-5397
dc.relation.doi http://dx.doi.org/10.3762/bjoc.10.49
dc.bibliographicCitation.volume 10
dc.bibliographicCitation.firstPage 535
dc.bibliographicCitation.lastPage 543
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


Thumbnail
Name: 1860-5397-10-49.pdf
Größe: 535.8Kb
Format: PDF
Öffnen

Die Publikation erscheint in Sammlung(en):

Zur Kurzanzeige

 

Suche im Repositorium


Durchblättern

Mein Nutzer/innenkonto

Nutzungsstatistiken