Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC

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dc.identifier.uri http://dx.doi.org/10.15488/584
dc.identifier.uri http://www.repo.uni-hannover.de/handle/123456789/608
dc.contributor.author Hass, Ralf
dc.contributor.author Kasper, Cornelia
dc.contributor.author Böhm, Stefanie
dc.contributor.author Jacobs, Roland
dc.date.accessioned 2016-10-31T10:06:39Z
dc.date.available 2016-10-31T10:06:39Z
dc.date.issued 2011
dc.identifier.citation Hass, R.; Kasper, Cornelia; Böhm, Stefanie; Jacobs, R.: Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC. In: Cell Communication and Signaling 9 (2011), 12. DOI: http://dx.doi.org/10.1186/1478-811X-9-12
dc.description.abstract The mesenchymal stroma harbors an important population of cells that possess stem cell-like characteristics including self renewal and differentiation capacities and can be derived from a variety of different sources. These multipotent mesenchymal stem cells (MSC) can be found in nearly all tissues and are mostly located in perivascular niches. MSC have migratory abilities and can secrete protective factors and act as a primary matrix for tissue regeneration during inflammation, tissue injuries and certain cancers. These functions underlie the important physiological roles of MSC and underscore a significant potential for the clinical use of distinct populations from the various tissues. MSC derived from different adult (adipose tissue, peripheral blood, bone marrow) and neonatal tissues (particular parts of the placenta and umbilical cord) are therefore compared in this mini-review with respect to their cell biological properties, surface marker expression and proliferative capacities. In addition, several MSC functions including in vitro and in vivo differentiation capacities within a variety of lineages and immune-modulatory properties are highlighted. Differences in the extracellular milieu such as the presence of interacting neighbouring cell populations, exposure to proteases or a hypoxic microenvironment contribute to functional developments within MSC populations originating from different tissues, and intracellular conditions such as the expression levels of certain micro RNAs can additionally balance MSC function and fate. eng
dc.description.sponsorship DFG/SFB738/A5
dc.description.sponsorship DFG/EXC/REBIRTH
dc.language.iso eng
dc.publisher London : BioMed Central Ltd.
dc.relation.ispartofseries Cell Communication and Signaling 9 (2011)
dc.rights CC BY 2.0
dc.rights.uri https://creativecommons.org/licenses/by/2.0/
dc.subject gamma interferon eng
dc.subject Jagged1 eng
dc.subject mycophenolic acid eng
dc.subject rapamycin eng
dc.subject toll like receptor 3 eng
dc.subject adipogenesis eng
dc.subject age distribution eng
dc.subject binding affinity eng
dc.subject cell differentiation eng
dc.subject cell function eng
dc.subject cell hypoxia eng
dc.subject cell interaction eng
dc.subject cell lineage eng
dc.subject cell migration eng
dc.subject cell population eng
dc.subject cellular immunity eng
dc.subject density gradient centrifugation eng
dc.subject graft versus host reaction eng
dc.subject human eng
dc.subject immunogenicity eng
dc.subject immunomodulation eng
dc.subject immunoregulation eng
dc.subject in vitro study eng
dc.subject in vivo study eng
dc.subject low drug dose eng
dc.subject mesenchymal stem cell eng
dc.subject microenvironment eng
dc.subject nonhuman eng
dc.subject osteoblast eng
dc.subject oxidative stress eng
dc.subject placenta eng
dc.subject plasticity eng
dc.subject priority journal eng
dc.subject protein expression eng
dc.subject review eng
dc.subject synapse eng
dc.subject tissue distribution eng
dc.subject umbilical cord eng
dc.subject.ddc 500 | Naturwissenschaften ger
dc.subject.ddc 570 | Biowissenschaften, Biologie ger
dc.title Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC
dc.type article
dc.type Text
dc.relation.issn 1478-811X
dc.relation.doi http://dx.doi.org/10.1186/1478-811X-9-12
dc.bibliographicCitation.volume 9
dc.bibliographicCitation.firstPage 12
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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