Development of a combined OCT-Raman probe for the prospective in vivo clinical melanoma skin cancer screening

Mazurenka, M.; Behrendt, L.; Meinhardt-Wollweber, Merve; Morgner, Uwe; Roth, B.

Original version

Mazurenka, M.; Behrendt, L.; Meinhardt-Wollweber, M.; Morgner, U.; Roth, B.: Development of a combined OCT-Raman probe for the prospective in vivo clinical melanoma skin cancer screening. In: Review of Scientific Instruments 88 (2017), Nr. 10, 105103. DOI: https://doi.org/10.1063/1.5004999

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To cite the version in the repository, please use this identifier: https://doi.org/10.15488/3291

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Abstract:
A combined optical coherence tomography (OCT)-Raman probe was designed and built into a spectral domain OCT head, and its performance was evaluated and compared to the most common Raman probe setups, based on a fiber bundle and confocal free space optics. Due to the use of the full field of view of an OCT scanning lens, the combined probe has a superior performance within maximum permissible exposure limits, compared to the other two probes. Skin Raman spectra, recorded in vivo, further prove the feasibility of the OCT-Raman probe for the future in vivo clinical applications in skin cancer screening. © 2017 Author(s).
License of this version:	Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden.
Publication type:	Article
Publishing status:	publishedVersion
Publication date:	2017
Keywords english:	Dermatology, Diseases, Probes, Clinical application, Combined probes, Fiber bundles, Field of views, Free space optics, Maximum permissible exposure, Skin cancers, Spectral domain OCT, Optical tomography, diagnostic imaging, early cancer diagnosis, human, melanoma, optical coherence tomography, skin tumor, Early Detection of Cancer, Humans, Melanoma, Skin Neoplasms, Tomography, Optical Coherence
DDC:	530 \| Physik