dc.identifier.uri |
http://dx.doi.org/10.15488/3051 |
|
dc.identifier.uri |
http://www.repo.uni-hannover.de/handle/123456789/3081 |
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dc.contributor.author |
Hothorn, Ludwig A.
|
|
dc.date.accessioned |
2018-03-01T13:28:38Z |
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dc.date.available |
2018-03-01T13:28:38Z |
|
dc.date.issued |
2006 |
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dc.identifier.citation |
Hothorn, L.A.: Statistical Analysis of in Vivo Anticancer Experiments: Tumor Growth Inhibition. In: Therapeutic Innovation & Regulatory Science 40 (2006), Nr. 2, S. 229-238. DOI: https://doi.org/10.1177/009286150604000212 |
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dc.description.abstract |
Tumor growth inhibition data in in vivo anticancer experiments are commonly analyzed using the treatment-to-control ratio (TCR). Parametric and nonparametric confidence interval approaches for this ratio are introduced, enabling a quantitative statistical decision. The growth curves are characterized by the area-under-the-curve technique, adjusted for animal-specific survival. Simple simultaneous approaches are proposed for complex designs, including several treatment or dose groups. This implementation makes decision making easier for the pharmacologists through the use of simple diagrams for the treatment-to-control ratios and their confidence intervals. Tumor inhibition and regression can be appropriately statistically analyzed by treatment-to-control ratios and their confidence intervals. © 2006, Drug Information Association. All rights reserved. |
eng |
dc.language.iso |
eng |
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dc.publisher |
London : SAGE Publications Ltd. |
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dc.relation.ispartofseries |
Therapeutic Innovation & Regulatory Science 40 (2006), Nr. 2 |
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dc.rights |
Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
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dc.subject |
Confidence intervals |
eng |
dc.subject |
Treatment-to-control ratio |
eng |
dc.subject |
Tumor inhibition |
eng |
dc.subject.ddc |
610 | Medizin, Gesundheit
|
ger |
dc.title |
Statistical Analysis of in Vivo Anticancer Experiments: Tumor Growth Inhibition |
eng |
dc.type |
Article |
|
dc.type |
Text |
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dc.relation.issn |
2168-4790 |
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dc.relation.doi |
https://doi.org/10.1177/009286150604000212 |
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dc.bibliographicCitation.issue |
2 |
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dc.bibliographicCitation.volume |
40 |
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dc.bibliographicCitation.firstPage |
229 |
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dc.bibliographicCitation.lastPage |
238 |
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dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
|