Zusammenfassung: | |
The clastogenic effect of total dichloromethane, methanol and water extracts, four bioactive fractions and three individual constituents from Carthamus lanatus aerial parts were evaluated in mice by bone marrow chromosome aberration assay with mitomycin C as positive control. Significant differences in the percentage of aberrant mitosis of the extracts were observed. The dichloromethane extract exhibited a considerable clastogenic effect and the water extract a negligible one. Different types of chromosome aberrations and time-dependant effects for the active fractions and individual compounds were found.
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Lizenzbestimmungen: | CC BY-NC-ND 3.0 Unported - https://creativecommons.org/licenses/by-nc-nd/3.0/ |
Publikationstyp: | Article |
Publikationsstatus: | publishedVersion |
Erstveröffentlichung: | 2003 |
Schlagwörter (englisch): | Carthamus lanatus, Clastogenic Effect, dichloromethane, dimethyl sulfoxide, methanol, mutagenic agent, plant extract, solvent, water, analysis of variance, animal, article, Carthamus, chemistry, chromosome aberration, comparative study, female, Institute for Cancer Research mouse, isolation and purification, male, mouse, plant, Analysis of Variance, Animals, Carthamus, Chromosome Aberrations, Dimethyl Sulfoxide, Female, Male, Methanol, Methylene Chloride, Mice, Mice, Inbred ICR, Mutagens, Plant Components, Aerial, Plant Extracts, Solvents, Water, Animalia, Asteraceae, Carthamus, Carthamus lanatus |
Fachliche Zuordnung (DDC): | 570 | Biowissenschaften, Biologie |
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