Franke, J.; Eichner, S.; Zeilinger, C.; Kirschning, A.: Targeting heat-shock-protein 90 (Hsp90) by natural products: Geldanamycin, a show case in cancer therapy. In: Natural Product Reports 30 (2013), Nr. 10, S. 1299-1323. DOI:
https://doi.org/10.1039/c3np70012g
Abstract: |
Covering: 2005 to 2013 In this review recent progress in the development of heat shock proteins (Hsp90) in oncogenesis is illuminated. Particular emphasis is put on inhibitors such as geldanamycin and analogues that serve as a natural product show case. Hsp90 has emerged as an important target in cancer therapy and/or against pathogenic cells which elicit abnormal Hsp patterns. Competition for ATP by geldanamycin and related compounds abrogate the chaperone function of Hsp90. In this context, this account pursues three topics in detail: a) Hsp90 and its biochemistry, b) Hsp90 and its role in oncogenesis and c) strategies to create compound libraries of structurally complex inhibitors like geldanamycin on which SAR studies and the development of drugs that are currently in different stages of clinical testing rely. © The Royal Society of Chemistry 2013.
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License of this version: |
Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
Publication type: |
Article |
Publishing status: |
publishedVersion |
Publication date: |
2013 |
Keywords english: |
antineoplastic agent, benzoquinone derivative, biological product, geldanamycin, heat shock protein 90, macrocyclic lactam, chemical structure, chemistry, combinatorial chemistry, drug antagonism, drug design, human, review, synthesis, Antineoplastic Agents, Benzoquinones, Biological Products, Combinatorial Chemistry Techniques, Drug Design, HSP90 Heat-Shock Proteins, Humans, Lactams, Macrocyclic, Molecular Structure
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DDC: |
540 | Chemie
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