- Startseite
- →
- Fakultäten
- →
- Naturwissenschaftliche Fakultät
- →
- Dokumentanzeige
JavaScript is disabled for your browser. Some features of this site may not work without it.
Originalpublikation
Chen, W.; Chen, R.; Liu, Q.; He, Y.; He, K. et al.: Orange, red, yellow: Biosynthesis of azaphilone pigments in Monascus fungi. In: Chemical Science 8 (2017), Nr. 7, S. 4917-4925. DOI: https://doi.org/10.1039/c7sc00475c
Version im Repositorium
Zum Zitieren der Version im Repositorium verwenden Sie bitte diesen DOI:
https://doi.org/10.15488/1799
| Zusammenfassung: | |
|
Monascus azaphilone pigments (MonAzPs) are very widely used as food colorants, but their biosynthetic pathway has remained poorly characterized for more than half a century. In this study, the individual steps of MonAzPs biosynthesis in Monascus ruber M7 were elucidated by a combination of targeted gene knockouts, heterologous gene expression, and in vitro chemical and enzymatic reactions. This study describes the first rational engineering of MonAzPs biosynthesis and provides a roadmap for future pathway engineering efforts directed towards the selective production of the most valuable pigments and serves as a model for the biosynthesis of fungal azaphilones in general.
|
|
| Lizenzbestimmungen: | CC BY-NC 3.0 Unported - https://creativecommons.org/licenses/by-nc/3.0/ |
| Publikationstyp: | Article |
| Publikationsstatus: | publishedVersion |
| Erstveröffentlichung: | 2017 |
| Schlagwörter (englisch): | Biochemistry, Gene expression, Genes, Biosynthetic pathway, Enzymatic reaction, Food colorants, Gene knockout, Heterologous gene expressions, In-vitro, Pathway engineerings, Selective production, Biosynthesis |
| Fachliche Zuordnung (DDC): | 540 | Chemie |
Die Publikation erscheint in Sammlung(en):
-
Naturwissenschaftliche Fakultät
Frei zugängliche Publikationen aus der Naturwissenschaftlichen Fakultät