dc.identifier.uri |
http://dx.doi.org/10.15488/12618 |
|
dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/12718 |
|
dc.contributor.author |
Feng, Jin
|
|
dc.contributor.author |
Surup, Frank
|
|
dc.contributor.author |
Hauser, Maurice
|
|
dc.contributor.author |
Miller, Anna
|
|
dc.contributor.author |
Wennrich, Jan-Peer
|
|
dc.contributor.author |
Stadler, Marc
|
|
dc.contributor.author |
Cox, Russel J.
|
|
dc.contributor.author |
Kuhnert, Eric
|
|
dc.date.accessioned |
2022-08-04T08:31:55Z |
|
dc.date.available |
2022-08-04T08:31:55Z |
|
dc.date.issued |
2020 |
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dc.identifier.citation |
Feng, J.; Surup, F.; Hauser, M.; Miller, A.; Wennrich, J.-P. et al.: Biosynthesis of oxygenated brasilane terpene glycosides involves a promiscuous N-acetylglucosamine transferase. In: Chemical Communications 56 (2020), Nr. 82, S. 12419-12422. DOI: https://doi.org/10.1039/d0cc03950k |
|
dc.description.abstract |
Investigation of the metabolome of the ascomycete Annulohypoxylon truncatum led to the identification of novel oxygenated brasilane glycosides and the revision of the stereochemistry of the brasilane A octahydro-1H-indene core scaffold to trans. The bra biosynthetic gene cluster containing five genes (braA–braE) was identified and verified by heterologous expression experiments in Aspergillus oryzae demonstrating that BraC is a multifunctional P450 monooxygenase. In vitro studies of BraB revealed it to be a very rare fungal UDP-GlcNAc dependent N-acetylglucosamine transferase. UDP-glucose is also accepted as a donor, and a broad acceptor substrate tolerance for various primary and secondary alcohols was observed. |
eng |
dc.language.iso |
eng |
|
dc.publisher |
London : Royal Society of Chemistry (RSC) |
|
dc.relation.ispartofseries |
Chemical Communications 56 (2020), Nr. 82 |
|
dc.rights |
CC BY 3.0 Unported |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/3.0/ |
|
dc.subject |
Annulohypoxylon truncatum |
eng |
dc.subject |
biosynthetic gene cluster |
eng |
dc.subject |
Aspergillus oryzae |
eng |
dc.subject |
monooxygenase |
eng |
dc.subject.ddc |
540 | Chemie
|
ger |
dc.title |
Biosynthesis of oxygenated brasilane terpene glycosides involves a promiscuous N-acetylglucosamine transferase |
|
dc.type |
Article |
|
dc.type |
Text |
|
dc.relation.essn |
1364-548X |
|
dc.relation.issn |
0009-241X |
|
dc.relation.issn |
0022-4936 |
|
dc.relation.issn |
1359-7345 |
|
dc.relation.doi |
https://doi.org/10.1039/d0cc03950k |
|
dc.bibliographicCitation.issue |
82 |
|
dc.bibliographicCitation.volume |
56 |
|
dc.bibliographicCitation.firstPage |
12419 |
|
dc.bibliographicCitation.lastPage |
12422 |
|
dc.description.version |
publishedVersion |
|
tib.accessRights |
frei zug�nglich |
|