dc.identifier.uri |
http://dx.doi.org/10.15488/1168 |
|
dc.identifier.uri |
http://www.repo.uni-hannover.de/handle/123456789/1192 |
|
dc.contributor.author |
Pilz, Stefan
|
|
dc.contributor.author |
Hahn, Andreas
|
|
dc.contributor.author |
Schön, Christiane
|
|
dc.contributor.author |
Wilhelm, Manfred
|
|
dc.contributor.author |
Obeid, Rima
|
|
dc.date.accessioned |
2017-02-24T08:49:30Z |
|
dc.date.available |
2017-02-24T08:49:30Z |
|
dc.date.issued |
2017 |
|
dc.identifier.citation |
Pilz, S.; Hahn, Andreas; Schön, C.; Wilhelm, M. et al.: Effect of two different multimicronutrient supplements on vitamin D status in women of childbearing age: A randomized trial. In: Nutrients 9 (2017), Nr. 1, 30. DOI: https://doi.org/10.3390/nu9010030 |
|
dc.description.abstract |
The German Nutrition Society raised in 2012 the recommended daily vitamin D intake from 200 to 800 international units (IU) to achieve 25-hydroxyvitamin D (25 (OH) D) levels of at least 50 nmol/L, even when endogenous vitamin D synthesis is minimal such as in winter. We aimed to evaluate this recommendation in women of childbearing age. This is a single-center, randomized, open trial conducted from 8 January to 9 May 2016 in Esslingen, Germany. We randomized 201 apparently healthy women to receive for 8 weeks a daily multimicronutrient supplement containing either 200 IU (n = 100) or 800 IU vitamin D3 (n = 101). Primary outcome measure was serum 25 (OH) D. 196 participants completed the trial. Increases in 25 (OH) D (median with interquartile range) from baseline to study end were 13.2 (5.9 to 20.7) nmol/L in the 200 IU group, and 35.8 (18.2 to 52.8) nmol/L in the 800 IU group (p < 0.001 for the between group difference). At study end, levels of ≥50 nmol/L were present in 70.4% of the 200 IU group and in 99% of the 800 IU group. Participants on hormonal contraceptives had higher baseline levels and a stronger increase in 25 (OH) D. In conclusion, daily supplementation of 800 IU vitamin D3 during wintertime in Germany is sufficient to achieve a 25 (OH) D level of at least 50 nmol/L in almost all women of childbearing age, whereas 200 IU are insufficient. |
eng |
dc.language.iso |
eng |
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dc.publisher |
Basel : MDPI AG |
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dc.relation.ispartofseries |
Nutrients 9 (2017), Nr. 1 |
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dc.rights |
CC BY-NC-SA 4.0 Unported |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
|
dc.subject |
25(OH)D |
eng |
dc.subject |
Multimicronutrient |
eng |
dc.subject |
Randomized controlled trial |
eng |
dc.subject |
Supplementation |
eng |
dc.subject |
Vitamin D |
eng |
dc.subject |
Women |
eng |
dc.subject.ddc |
500 | Naturwissenschaften
|
ger |
dc.title |
Effect of two different multimicronutrient supplements on vitamin D status in women of childbearing age: A randomized trial |
|
dc.type |
Article |
|
dc.type |
Text |
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dc.relation.issn |
2072-6643 |
|
dc.relation.doi |
https://doi.org/10.3390/nu9010030 |
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dc.bibliographicCitation.issue |
1 |
|
dc.bibliographicCitation.volume |
9 |
|
dc.bibliographicCitation.firstPage |
30 |
|
dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
|