dc.identifier.uri |
http://dx.doi.org/10.15488/1017 |
|
dc.identifier.uri |
http://www.repo.uni-hannover.de/handle/123456789/1041 |
|
dc.contributor.author |
Heinz, Tina
|
|
dc.contributor.author |
Schuchardt, Jan Philipp
|
|
dc.contributor.author |
Möller, Katharina
|
|
dc.contributor.author |
Hadji, Peyman
|
|
dc.contributor.author |
Hahn, Andreas
|
|
dc.date.accessioned |
2017-01-12T08:11:05Z |
|
dc.date.available |
2017-01-12T08:11:05Z |
|
dc.date.issued |
2016 |
|
dc.identifier.citation |
Heinz, T.; Schuchardt, J.P.; Möller, K.; Hadji, P.; Hahn, A.: Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention. In: Nutrition Research 36 (2016), Nr. 10, S. 1162-1170. DOI: http://dx.doi.org/10.1016/j.nutres.2016.07.005 |
|
dc.description.abstract |
Hypercholesterolemia and elevated homocysteine concentrations are associated with cardiovascular risk. Previous studies have demonstrated a cholesterol-lowering effect of red yeast rice (RYR) supplements which contained 5 to 10 mg of monacolin K. We hypothesized that the intake of a low monacolin K dose may likewise reduce low-density lipoprotein–cholesterol (LDL-C) and other plasma lipids. In secondary analyses, we tested the homocysteine lowering effect of folic acid, which was also included in the study preparation. Therefore, we conducted a randomized, double-blind, and placebo-controlled intervention study. One hundred forty-two nonstatin-treated participants with hypercholesterolemia (LDL-C ≥ 4.14 ≤ 5.69 mmol/L) were randomized to the supplement group with RYR or the placebo group. Participants of the supplement group consumed 3 mg monacolin K and 200 μg folic acid per day. A significant (P < .001) reduction of LDL-C (−14.8%), total cholesterol (−11.2%), and homocysteine (−12.5%) was determined in the supplement group after 12 weeks. A total of 51% of the participants treated with RYR achieved the limit of LDL-C <4.14 mmol/L advised and 26% reached the threshold level of homocysteine <10 μmol/L. No significant changes were exhibited within the placebo group. Other parameters remained unchanged and no intolerances or serious adverse events were observed. In conclusion, we demonstrated that a low dose of daily 3 mg monacolin K from RYR reduces the concentration of LDL-C; a risk factor for cardiovascular diseases. |
eng |
dc.language.iso |
eng |
|
dc.publisher |
New York : Elsevier Inc. |
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dc.relation.ispartofseries |
Nutrition Research 36 (2016), Nr. 10 |
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dc.rights |
CC BY-NC-ND 4.0 Unported |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
dc.subject |
Folic acid |
eng |
dc.subject |
Homocysteine |
eng |
dc.subject |
LDL-cholesterol |
eng |
dc.subject |
Monacolin K |
eng |
dc.subject |
Red yeast rice |
eng |
dc.subject.ddc |
500 | Naturwissenschaften
|
ger |
dc.title |
Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention |
|
dc.type |
Article |
|
dc.type |
Text |
|
dc.relation.issn |
0271-5317 |
|
dc.relation.doi |
https://doi.org/10.1016/j.nutres.2016.07.005 |
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dc.bibliographicCitation.issue |
10 |
|
dc.bibliographicCitation.volume |
36 |
|
dc.bibliographicCitation.firstPage |
1162 |
|
dc.bibliographicCitation.lastPage |
1170 |
|
dc.description.version |
publishedVersion |
|
tib.accessRights |
frei zug�nglich |
|