NIR-spectroscopy for bioprocess monitoring & control

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Sandor, Marko; Rüdinger, Ferdinand; Solle, Dörte; Bienert, Roland; Grimm et al.: NIR-spectroscopy for bioprocess monitoring & control. In: BMC Proceedings 7 (2013), Suppl. 6, P29. DOI: http://dx.doi.org/10.1186/1753-6561-7-S6-P29

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To cite the version in the repository, please use this identifier: https://doi.org/10.15488/488

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Sum total of downloads: 178




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Abstract: 
The Ingold port adaption of a free beam NIR spectrometer is tailored for optimal bioprocess monitoring and control. The device shows an excellent signal to noise ratio dedicated to a large free aperture and therefore a large sample volume. This can be seen particularly in the batch trajectories which show a high reproducibility. The robust and compact design withstands rough process environments as well as SIP/CIP cycles. Robust free beam NIR process analyzers are indispensable tools within the PAT/QbD framework for realtime process monitoring and control. They enable multiparametric, non-invasive measurements of analyte concentrations and process trajectories. Free beam NIR spectrometers are an ideal tool to define golden batches and process borders in the sense of QbD. Moreover, sophisticated data analysis both quantitative and MSPC yields directly to a far better process understanding. Information can be provided online in easy to interpret graphs which allow the operator to make fast and knowledge-based decisions. This finally leads to higher stability in process operation, better performance and less failed batches.
License of this version: CC BY 2.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2013
Appears in Collections:Naturwissenschaftliche Fakultät

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downloads by country:

pos. country downloads
total perc.
1 image of flag of Germany Germany 126 70.79%
2 image of flag of United States United States 24 13.48%
3 image of flag of China China 8 4.49%
4 image of flag of Russian Federation Russian Federation 4 2.25%
5 image of flag of France France 3 1.69%
6 image of flag of Australia Australia 2 1.12%
7 image of flag of Taiwan Taiwan 1 0.56%
8 image of flag of Serbia Serbia 1 0.56%
9 image of flag of Italy Italy 1 0.56%
10 image of flag of Israel Israel 1 0.56%
    other countries 7 3.93%

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