Work-related illnesses and the resulting employee absences can have a major impact on productivity and competitiveness, especially in small and medium-sized enterprises. Particularly in the forging industry, the manual handling of forged parts leads to high physical stress and thus to frequent illnesses of the musculoskeletal system, especially of the hand-arm system. One possibility to counteract this circumstance is the use of ergonomic forging tongs. In the study presented here, the influence of ergonomic forging tongs on the physical stress of forging employees was investigated by simulation and experiment and compared to conventional forging tongs. Within the simulation and the experimental investigation, forging parts and forging tongs were varied. In the simulation, an ergonomics assessment of the forging situation could be evaluated using the Ergonomic Assessment Worksheet. In the experimental study, gripping force measurements and calorie measurements were used to determine the impact of handling the forging tongs on the forging employees. The results show that the use of the new ergonomically optimized forging tongs can lead to a significant physical relief for the forging employees. The knowledge gained from the ergonomically developed concepts can also be transferred in other industries.