Auflistung nach Schlagwort "Polyketides"

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  • Azaphilone Pigments from Hypoxylon rubiginosum and H. texense: Absolute Configuration, Bioactivity, and Biosynthesis 
    Becker, Kevin; Kuhnert, Eric; Cox, Russell J.; Surup, Frank (Weinheim : Wiley-VCH Verl., 2021)
    We report new stromatal azaphilone pigments rubiginosins Z-X from the ascomycete Hypoxylon rubiginosum, as well as rubiginosins Z and W from H. texense, which were isolated along with known monomeric and dimeric congeners. ...
  • Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides 
    Hemmerling, Franziska; Hahn, Frank (Frankfurt am Main : Beilstein-Institut zur Förderung der Chemischen Wissenschaften, 2016)
    This review highlights the biosynthesis of heterocycles in polyketide natural products with a focus on oxygen and nitrogen-containing heterocycles with ring sizes between 3 and 6 atoms. Heterocycles are abundant structural ...
  • Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human- and Animal-Pathogenic Burkholderia Species 
    Trottmann, Felix; Franke, Jakob; Richter, Ingrid; Ishida, Keishi; Cyrulies, Michael; Dahse, Hans-Martin; Regestein, Lars; Hertweck, Christian (Weinheim : Wiley-VCH Verlag, 2019)
    Burkholderia species such as B. mallei and B. pseudomallei are bacterial pathogens causing fatal infections in humans and animals (glanders and melioidosis), yet knowledge on their virulence factors is limited. While ...
  • Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis 
    Williams, Katherine; Szwalbe, Agnieszka J.; Mulholland, Nicholas P.; Vincent, Jason L.; Bailey, Andrew M.; Willis, Christine L.; Simpson, Thomas J.; Cox, Russell J. (Weinheim : Wiley-VCH Verlag, 2016)
    Fungal maleidrides are an important family of bioactive secondary metabolites that consist of 7, 8, or 9-membered carbocycles with one or two fused maleic anhydride moieties. The biosynthesis of byssochlamic acid (a ...
  • Maleidride biosynthesis - construction of dimeric anhydrides - more than just heads or tails 
    Williams, Katherine; Szwalbe, Agnieszka J.; de Mattos-Shipley, Kate M. J.; Bailey, Andy M.; Cox, Russell J.; Willis, Christine L. (London : Soc., 2023)
    Covering: up to early 2022 Maleidrides are a family of polyketide-based dimeric natural products isolated from fungi. Many maleidrides possess significant bioactivities, making them attractive pharmaceutical or agrochemical ...
  • Minimum Information about a Biosynthetic Gene cluster 
    Medema, Marnix H.; Kottmann, Renzo; Yilmaz, Pelin; Cummings, Matthew; Biggins, John B.; Cox, Russell J.; et al. (London : Nature Publishing Group, 2015)
    A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is ...
  • Total synthesis of elansolids B1 and B2 
    Wang, Liang-Liang; Kirschning, Andreas (Frankfurt am Main : Beilstein-Institut zur Förderung der Chemischen Wissenschaften, 2017)
    The elansolids A1–A3, B1, and B2 are secondary metabolites formed by the gliding bacterium Chitinophaga sancti. They show antibacterial activity against Gram-positive bacteria. A second generation total synthesis of the ...